Correlation between triglyceride-glucose-body mass index and the outcome of young patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2025.04.001
- VernacularTitle:甘油三酯葡萄糖-体重指数与青年急性缺血性卒中患者转归的相关性
- Author:
Xiangqing WANG
1
;
Fengzhi ZHAO
;
Yujing WANG
;
Ji WANG
;
Chao ZHEN
;
Xin WANG
Author Information
1. 青岛大学，青岛 266000
- Keywords:
Ischemic stroke;
Triglycerides;
Blood glucose;
Body mass index;
Biomarkers;
Treatment outcome;
Risk factors;
Young adult
- From:
International Journal of Cerebrovascular Diseases
2025;33(4):241-245
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between triglyceride-glucose-body mass index (TyG-BMI index) and the outcome of young patients with acute ischemic stroke (AIS).Methods:Consecutive young patients with first-ever AIS (aged 18-45 years) admitted to Pingyi County People's Hospital and Qingdao Municipal Hospital from January 2020 to December 2023 were included retrospectively. The demographic data, vascular risk factors, baseline blood pressure, baseline laboratory tests, classification of stroke etiology, baseline National Institutes of Health Stroke Scale (NIHSS) scores, and main treatment methods were collected. At 3 months after the onset of stroke, the modified Rankin Scale was used for outcome evaluation. A score of 0-2 was defined as good outcome and >2 were defined as poor outcome. Multivariate logistic regression analysis was used to identify independent factors associated with poor outcome in young patients with AIS. Results:A total of 253 young patients with AIS were enrolled, including 196 males (77.5%), aged 38.65±5.34 years; baseline NIHSS score 3.03±2.88. At 90 days after onset, 206 patients (81.4%) had good outcome, while 47 (18.6%) had poor outcome. The poor outcome group had significantly higher systolic blood pressure, triglycerides, fasting blood glucose, triglyceride glucose (TyG) index, body mass index (BMI), TyG-BMI index, and baseline NIHSS score than those of the good outcome group (all P<0.05). Multivariate logistic regression analysis showed that after adjusting for gender, systolic blood pressure, baseline NIHSS score, and antiplatelet drug use, the TyG-BMI index was significantly independently associated with the poor outcome in young patients with AIS (odds ratio 1.039, 95% confidence interval 1.021-1.057; P<0.001). Conclusion:A higher baseline TyG-BMI index is independently associated with the poor outcome in young patients with AIS.
