Osteopontin and ischemic stroke
10.3760/cma.j.issn.1673-4165.2025.03.009
- VernacularTitle:骨桥蛋白与缺血性卒中
- Author:
Minghui CHENG
1
;
Daojing LI
;
Qianqian WANG
;
Ziyou QI
Author Information
1. 济宁医学院，济宁 272000
- Keywords:
Ischemic stroke;
Osteopontin;
Embolic stroke;
Atrial fibrillation;
Inflammation;
Biomarkers
- From:
International Journal of Cerebrovascular Diseases
2025;33(3):213-216
- CountryChina
- Language:Chinese
-
Abstract:
Osteopontin (OPN) is a secreted extracellular matrix glycoprotein that exists in body fluids and mediates multiple biological functions. The expression of OPN is particularly critical and active after ischemic stroke, and has dual significance for the body. The rapid increase of OPN has certain protective effects on the body, such as anti-inflammatory and promoting wound healing; if the rate of increase is relatively slower, it will have adverse effects on the body, such as promoting thrombosis and inducing inflammatory reactions. This article reviews the research progress of OPN in ischemic stroke.
