Role of inflammation in early brain injury after subarachnoid hemorrhage
10.3760/cma.j.issn.1673-4165.2025.02.012
- VernacularTitle:炎症在蛛网膜下腔出血后早期脑损伤中的作用
- Author:
Dong XU
1
;
Yong SUN
Author Information
1. 徐州医科大学附属连云港医院神经外科，连云港 222000
- Keywords:
Subarachnoid hemorrhage;
Brain injuries;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2025;33(2):150-155
- CountryChina
- Language:Chinese
-
Abstract:
Subarachnoid hemorrhage (SAH) is a highly lethal neurological emergency. Researches have shown that the mechanism of delayed cerebral ischemia (DCI) and poor outcome in patients with SAH is no longer limited to cerebral vasospasm (CVS). Within 72 hours after the onset of SAH, early brain injury (EBI) typically triggers subsequent pathophysiological abnormalities and leads to poor outcome. The main mechanisms include increased intracranial pressure, oxidative stress, blood-brain barrier damage, inflammation, brain edema, and cell apoptosis. Among them, inflammation plays an important role in EBI and may be associated with DCI and poor long-term outcome. This article reviews the mechanism of inflammation in EBI after SAH and summarizes potential therapeutic drugs for immune inflammatory response in patients with SAH, in order to provide a theoretical basis for clinical research.
