Role of T lymphocytes in ischemic stroke
10.3760/cma.j.issn.1673-4165.2025.02.010
- VernacularTitle:T淋巴细胞在缺血性卒中中的作用
- Author:
Caimin CHEN
1
;
Linhui PENG
;
En XU
Author Information
1. 广州医科大学附属第二医院神经内科，广州医科大学神经科学研究所，广州 510260
- Keywords:
Ischemic stroke;
Brain ischemia;
T-Lymphocytes;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2025;33(2):138-143
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is the leading cause of death and disability among adults worldwide. T lymphocytes can be divided into αβT cells and γδT cells. Among them, αβT cells can be further divided into subgroups such as CD4? T cells, CD8? T cells, and natural killer (NK) cells. In CD4? T cells, T helper cells (Th) 1 and Th17 secrete pro-inflammatory cytokines, which can exacerbate ischemic brain injury; Th2 secretes anti-inflammatory factors, which can improve neurological function. Regulatory T cells (Tregs) exert neuroprotective effects through various mechanisms. CD8? T cells exacerbate ischemic brain injury by secreting cytokines and releasing granzyme, while NK cells can cause neuronal damage and blood-brain barrier damage by secreting interferon-γ. In addition, interleukin-17 secreted by γδT cells also plays a significant pro-inflammatory role in the pathological process of stroke. Therefore, a deeper understanding of the role of T lymphocytes can provide new ideas for the treatment of ischemic stroke.
