Correlation between plasma Dickkopf-1 and cognitive impairment after acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2025.02.002
- VernacularTitle:血浆Dickkopf-1与急性缺血性卒中后认知损害的相关性
- Author:
Jian SUN
1
;
Liqin LUAN
;
Wenbin WANG
;
Xuejun WANG
;
Hong SUN
;
Kejin YIN
Author Information
1. 南京江北医院急诊科，南京 210000
- Keywords:
Ischemic stroke;
Cognition disorders;
Intercellular signaling peptides and proteins;
Risk factors;
Biomarkers;
DKK1 protein, human
- From:
International Journal of Cerebrovascular Diseases
2025;33(2):87-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between plasma Dickkopf-1 (DKK1) and post-stroke cognitive impairment (PSCI) in patients with acute ischemic stroke.Methods:Consecutive patients with first-ever acute ischemic stroke admitted to the Department of Neurology, Nanjing Jiangbei Hospital from March 2023 to February 2024 were included prospectively. Enzyme-linked immunosorbent assay was used to detect plasma DKK1 within 24 hours of onset. The Montreal Cognitive Assessment Scale was used to evaluate cognitive function at 3 months after onset. A score ≤22 was defined as PSCI. Multivariate logistic regression analysis was used to determine the correlation between DKK1 and PSCI. The relationship between DKK1 and PSCI risks was evaluated through restrictive cubic spline analysis. Results:A total of 205 patients with acute ischemic stroke were enrolled, including 106 males (51.7%), aged 67.0±9.4 years; 61 patients (29.8%) experienced PSCI. Multivariate logistic regression analysis showed that after adjusting for age, gender, education level, and other confounding factors, there was a significant independent correlation between higher plasma DKK1 and PSCI (odds ratio 1.778, 95% confidence interval 1.313-2.408; P=0.001). Subgroup analysis showed that age, gender, etiological classification of stroke, and education level had no significant effect on the above correlation. Restrictive cubic spline analysis showed plasma DKK1 had a linear relationship with the risk of PSCI ( P=0.003). Conclusion:Higher plasma DKK1 level is significantly correlated with PSCI in patients with acute ischemic stroke at 90 days after onset.
