Correlation and possible mechanism between homocysteine and lacunar infarction
10.3760/cma.j.issn.1673-4165.2025.01.005
- VernacularTitle:高半胱氨酸与腔隙性梗死的相关性及其可能机制
- Author:
Qingyue GAN
1
;
Hongliang JIANG
;
Haixing FENG
;
Liming CAO
Author Information
1. 深圳大学医学部，深圳 518063
- Keywords:
Stroke, lacunar;
Homocysteine;
Hyperhomocysteinemia;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2025;33(1):30-35
- CountryChina
- Language:Chinese
-
Abstract:
Patients with lacunar infarction (LI) have a higher risk of stroke recurrence compared to other types of stroke, and it is an important pathological basis for vascular dementia. Homocysteine (Hcy) is closely associated with the occurrence and development of LI. The mechanism by which Hcy causes LI involves multiple complex biological processes (including inflammation, oxidative stress, endothelial dysfunction, etc.) and synergistic effects with various risk factors (such as hypertension and hyperglycemia), but the specific mechanism is currently not fully elucidated.
