Correlation between serum soluble intercellular adhesion molecule-1 and the severity of white matter hyperintensities
10.3760/cma.j.issn.1673-4165.2025.01.002
- VernacularTitle:血清可溶性细胞间黏附分子-1与脑白质高信号严重程度的相关性
- Author:
Lei CHEN
1
;
Shihua LIU
;
Caixia LIANG
;
Chao ZHANG
;
Yan CHEN
Author Information
1. 安徽医科大学附属宿州医院神经内科，宿州 234000
- Keywords:
White matter;
Cerebral small vessel diseases;
Intercellular adhesion molecule-1;
Magnetic resonance imaging;
Risk factors;
Biomarkers
- From:
International Journal of Cerebrovascular Diseases
2025;33(1):7-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between serum soluble intercellular adhesion molecule-1 (sICAM-1) and the severity of white matter hyperintensities (WMHs).Methods:Medical examinees in the Department of Neurology, Suzhou Hospital Affiliated to Anhui Medical University from February 2021 to October 2022 were selected as the research subjects. Head MRI was performed and the severity of WMHs was assessed by Fazekas scale. The enzyme-linked immunosorbent assay was used to detect serum sICAM-1 expression level. Multivariate logistic regression analysis was used to determine the independent influencing factors of the severity of WMHs. Results:A total of 171 subjects were enrolled, including 112 males (65.5%), aged 65.50±9.07 years. There were 92 patients (53.8%) with no WMH or mild WMHs and 79 patients (46.2%) with moderate to severe WMHs. The serum sICAM-1 levels in the moderate to severe WMH group were significantly higher than those in the no or milds WMH group ( t=5.679, P<0.001). Ordinal multivariate logistic regression analysis showed that after adjusting for confounding factors, higher sICAM-1 level was independently correlated with the severity of WMHs (compared to the 1 st quartile group, the 3 rd quartile group: odds ratio 3.149, 95% confidence interval 1.147-8.645, P=0.026; the 4 th quartile group: odds ratio 6.087, 95% confidence interval 2.051-18.061; P=0.001). Conclusion:Elevated serum sICAM-1 level is an independent influencing factor of WMHs.
