Association of monocyte-to-high-density lipoprotein cholesterol ratio with white matter hyperintensities and its spatial distribution
10.3760/cma.j.issn.1673-4165.2025.01.001
- VernacularTitle:单核细胞/高密度脂蛋白胆固醇比值与脑白质高信号及空间分布的相关性
- Author:
Junying JIANG
1
;
Cunsheng WEI
;
Yingying XUE
;
Peizhi GU
;
Xiaorong YU
;
Ying SHE
;
Xuemei CHEN
Author Information
1. 南京医科大学附属江宁医院神经内科，南京 211100
- Keywords:
Cerebral small vessel diseases;
White matter;
Monocytes;
Cholesterol, HDL;
Risk factors;
Biomarkers
- From:
International Journal of Cerebrovascular Diseases
2025;33(1):1-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of monocyte-to-high-density lipoprotein cholesterol ratio (MHR) with the severity of white matter hyperintensities (WMHs) and its spatial distribution.Methods:Patients admitted to the Department of Neurology, Jiangning Hospital Affiliated to Nanjing Medical University due to various chronic diseases or physical examinations between January 2023 and December 2024 were included retrospectively. Past medical history, clinical and imaging data were collected. The Fazekas scale was used to assess the severity of WMHs. According to the scoring results of periventricular WMHs (PVWMHs) and deep WMHs (DWMHs), WMHs were divided into no/mild group (0-1 points) and moderate/severe group (2-3 points). Multivariate logistic regression analysis was used to determine independent correlation factors for the severity of WMHs, PVWMHs, and DWMHs. Results:A total of 357 patients were included, aged 65.42±9.95 years, with 198 males (55.5%). There were 193 patients (54.1%) in the no/mild group and 164 (45.9%) in the moderate/severe group. Univariate analysis showed that the proportion of patients with hypertension, diabetes, history of cerebral infarction and cerebral hemorrhage, carotid plaque, and age, serum creatinine, monocyte count and MHR in the moderate/severe group were significantly higher than those in the no/mild group (all P<0.05). Multivariate logistic regression analysis showed a significant positive correlation between MHR and the severity of WMHs (odds ratio 3.138, 95% confidence interval 1.042-9.451; P=0.042). Further analysis showed a significant positive correlation between MHR and PVWMHs (odds ratio 3.384, 95% confidence interval 1.111-10.305; P=0.032), but no independent correlation with DWMHs. In addition, age and hypertension, diabetes, history of cerebral infarction and cerebral hemorrhage were significantly positively correlated with the severity of WMHs, PVWMHs and DWMHs. Conclusion:MHR is correlated with the severity of WMHs, and higher MHR is significantly associated with PVWMHs, but not with DWMHs.
