Associations of serum vascular endothelial growth factor and vascular endothelial growth factor receptor 2 with carotid plaque stability in elderly patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2024.12.007
- VernacularTitle:血清血管内皮生长因子、血管内皮生长因子受体2与老年急性缺血性卒中患者颈动脉斑块稳定性的相关性
- Author:
Yonggang KANG
1
;
Lu CHE
;
Yugang WANG
;
Shaoqiang CHENG
;
Li YAO
Author Information
1. 陕西省咸阳市第一人民医院神经内科二病区，咸阳 712000
- Keywords:
Ischemic stroke;
Carotid arteries;
Plaque, atherosclerotic;
Vascular endothelial growth factor A;
Receptors, vascular endothelial growth factor;
Predictive
- From:
International Journal of Cerebrovascular Diseases
2024;32(12):922-927
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate associations of serum vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR2) with carotid plaque stability in elderly patients with acute ischemic stroke (AIS).Methods:Elderly AIS patients with carotid plaque detected by carotid ultrasound in the First People's Hospital of Xianyang from April 2022 to April 2024 were selected, and they were further divided into stable plaque group and vulnerable plaque group. Multivariate logisitic regression analysis was used to determine the correlation between serum VEGF/VEGFR2 and carotid plaque stability. Receiver operating characteristic (ROC) curve was used to analyze the differential value of serum VEGF and VEGFR2 on plaque stability. Results:A total of 183 patients were enrolled, including 139 males (75.96%), aged 68.10±4.97 years. One hundred and one patients (55.19%) had vulnerable plaques, and 82 (44.81%) had stable plaques. There were significant differences in age, triglycerides, VEGF, VEGFR2, baseline National Institutes of Health Stroke Scale scores, and the proportion of patients with hypertension, diabetes, smoking, and statins between the vulnerable plaque group and the stable plaque group (all P<0.05). Multivariate logistic regression analysis showed that serum VEGF (odds ratio [ OR] 1.021, 95% confidence interval [ CI] 1.004-1.037; P=0.015] and VEGFR2 ( OR 1.009, 95% CI 1.005-1.012; P<0.001) were independently associated with vulnerable plaques. ROC curve analysis showed that serum VEGF and VEGFR2 alone were effective in distinguishing plaque stability, and the areas under the curve were 0.744 (95% CI 0.673-0.815) and 0.809 (95% CI 0.749-0.870), respectively. The area under the curve of the combination of the two was 0.874 (95% CI 0.825-0.924). Conclusion:Serum VEGF and VEGFR2 are independently associated with vulnerable carotid plaques in elderly patients with AIS, and both alone or in combination have good discriminatory value for the stability of carotid plaques.
