Correlation between fibrinogen/albumin ratio and overall burden of cerebral small vessel disease
10.3760/cma.j.issn.1673-4165.2024.11.006-1
- VernacularTitle:纤维蛋白原/白蛋白比值与脑小血管病总体负担的相关性
- Author:
Juan FU
1
;
Qiongqiong HU
;
Yidi LI
;
Wenpei LI
;
Gaiqing YANG
Author Information
1. 郑州大学第二附属医院，郑州 450001
- Keywords:
Cerebral small vessel diseases;
Fibrinogen;
Albumins;
Risk factors;
Predictive value of tests;
Magnetic resonance imaging;
Biomarkers
- From:
International Journal of Cerebrovascular Diseases
2024;32(12):916-921
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between fibrinogen/albumin ratio (FAR) and overall burden of cerebral small vessel disease (CSVD).Methods:Patients with CSVD who visited the Department of Neurology, Zhengzhou Central Hospital Affiliated to Zhengzhou University from May 2023 to May 2024 were included retrospectively. All patients underwent MRI to evaluate the total CSVD burden score (range: 0-4) by cerebral microbleeds, white matter hyperintensities, lacunar and enlarged perivascular spaces. 0-1 point was the mild burden group, and 2-4 points were the moderate-to-severe burden group. FAR was calculated as serum fibrinogen (g/L)/albumin (g/L)×100%. Spearman correlation analysis and multivariate logistic regression analysis were used to determine the relationship between FAR and total CSVD burden. Results:A total of 261 patients with CSVD were enrolled, including 145 males (55.6%), aged 64.08±8.74 years. There were 110 patients (42.1%) in the CSVD mild burden group and 151 (57.9%) in the moderate-to-severe burden group. Spearman correlation analysis showed that there was a significant positive correlation between FAR and total CSVD burden scores ( r=0.385, P<0.001). Univariate analysis showed that the proportion of patients with diabetes, history of stroke or transient ischemic attack, as well as age, FAR, homocysteine and fibrinogen in the CSVD moderate-to-severe burden group were significantly higher than those in the mild burden group, while serum albumin and high-density lipoprotein cholesterol were significantly lower in the mild burden group (all P<0.05). Multivariate logistic regression analysis showed that higher FAR (odds ratio 1.433, 95% confidence interval 1.201-1.710; P<0.001) and homocysteine (odds ratio 1.093, 95% confidence interval 1.026-1.164; P=0.005) were significantly independently associated with the moderate-to-severe total CSVD burden. Conclusion:The level of FAR is closely associated with the severity of the total CSVD burden in patients with CSVD.
