Associations of neutrophil-to-high-density lipoprotein cholesterol ratio and monocyte-to-high-density lipoprotein cholesterol ratio with carotid plaque and its vulnerability in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2024.11.007
- VernacularTitle:中性粒细胞/高密度脂蛋白胆固醇比值和单核细胞/高密度脂蛋白胆固醇比值与急性缺血性卒中患者颈动脉斑块及其易损性的相关性
- Author:
Shan GAO
1
;
Yixuan WANG
;
Xinying GUAN
Author Information
1. 徐州医科大学附属连云港医院神经内科，连云港 222000
- Keywords:
Ischemic stroke;
Carotid stenosis;
Plaque, atherosclerotic;
Cholesterol, HDL;
Neutrophils;
Monocytes;
Ultrasonography;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2024;32(11):839-844
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate associations of neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) with carotid plaque and its vulnerability in patients with acute ischemic stroke (AIS).Methods:Consecutive patients with first-ever AIS admitted to the Department of Neurology, the First People's Hospital of Lianyungang from January 1, 2022 to January 31, 2023 were enrolled retrospectively. According to the carotid ultrasound findings after admission, they were divided into a non-plaque group and a plaque group. The latter was further divided into a stable plaque group and a vulnerable plaque group. Multivariate logistic regression analysis was used to evaluate the independent risk factors for carotid plaque and its vulnerability. The odds ratio ( OR) and its 95% confidence interval ( CI) were calculated. Results:A total of 369 patients with AIS were enrolled, including 259 males (70.20%), with a median age of 63.00 years (interquartile range, 56.00-70.00 years). There were 20 patients (5.42%) in the non-plaque group and 349 (94.58%) in the plaque group, including 142 (40.69%) in the stable plaque group and 207 (59.31%) in the vulnerable plaque group. Multivariate logistic regression analysis showed that higher NHR ( OR 2.558, 95% CI 1.068-6.126; P=0.035) and higher MHR ( OR 2.312, 95% CI 1.111-4.814; P=0.025) were the independent risk factors for carotid plaques; advanced age ( OR 1.069, 95% CI 1.037-1.103; P<0.001), alcohol consumption ( OR 2.072, 95% CI 1.049-4.092; P=0.036), higher NHR ( OR 1.521, 95% CI 1.146-2.019; P=0.004), and higher MHR ( OR 1.765, 95% CI 1.388-2.244; P<0.001) were the independent risk factors for vulnerable carotid plaques. Conclusion:Higher NHR and MHR are associated with carotid plaque and its vulnerability in patients with AIS.
