Correlation between serum proprotein convertase subtilisin/kexin type 9 and white matter hyperintensities of presumed vascular origin in healthy individuals
10.3760/cma.j.issn.1673-4165.2024.10.006
- VernacularTitle:血清前蛋白转化酶枯草杆菌蛋白酶/kexin 9型与健康体检者血管源性脑白质高信号的相关性
- Author:
Xiuli SHU
1
;
Yun LI
;
Zhenqian HUANG
;
Ying ZHAO
;
Xiaohao ZHANG
;
Wusheng ZHU
;
Yi XIE
;
Xinfeng LIU
Author Information
1. 南京大学医学院附属金陵医院神经内科，南京 210002
- Keywords:
White matter;
Cerebral small vessel diseases;
Severity of illness index;
Proprotein convertase 9;
Magnetic resonance imaging;
Risk factors;
Biomarkers
- From:
International Journal of Cerebrovascular Diseases
2024;32(10):754-759
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between serum proprotein convertase subtilisin/Kexin type 9 (PCSK9) level and white matter hyperintensities (WMHs) in healthy population.Methods:Consecutive healthy individuals underwent routine physical examinations at the Department of Neurology, Jinling Hospital Affiliated to Medical School of Nanjing University (April 2023 to December 2023) and Hexi Branch of Nanjing First Hospital (March 2024 to April 2024) were included prospectively. Enzyme-linked immunosorbent assay was used to detect serum PCSK9 level. The Fazekas scale was used to assess the severity of WMHs (total score 0-6) and they were divided into no or mild WMHs group (0-2) and moderate to severe WMHs group (3-6). Multivariate logistic regression analysis was used to determine the independent correlation between the serum PCSK9 level and the severity of WMHs. Results:A total of 177 subjects were enrolled, including 110 males (62.1%), aged 66.7±10.1 years. The median serum PCSK9 level was 203.9 ng/L. According to the Fazekas score, there were 102 patients (51.6%) in the no or mild WMHs group, and 75 (42.4%) in the moderate to severe WMHs group. One way analysis of variance showed that serum PCSK9 level significantly increased with the increase of WMHs total score ( P=0.001). The serum PCSK9 level in the moderate to severe WMHs group was significantly higher than that in the no or mild WMHs group (437.2±260.4 ng/L vs. 217.9±141.7 ng/L; P=0.001). Multivariate logistic regression analysis showed that after adjusting for age, gender, and other confounding factors, there was a significant independent correlation between higher serum PCSK9 level and moderate to severe WMHs (odds ratio 3.201, 95% confidence interval 2.107-5.082; P=0.001). Conclusion:Higher serum PCSK9 level is an independent risk factor for moderate to severe WMHs in healthy individuals.
