Correlation between homeostasis model assessment for insulin resistance index and post-stroke cognitive impairment in patients with minor ischemic stroke
10.3760/cma.j.issn.1673-4165.2024.09.005
- VernacularTitle:稳态模型评估的胰岛素抵抗指数与轻型缺血性卒中患者卒中后认知损害的相关性
- Author:
Jun YANG
1
;
Zhiqiang QI
;
Minyan LU
Author Information
1. 南京医科大学附属江苏盛泽医院神经内科，苏州 215228
- Keywords:
Ischemic stroke;
Cognition disorders;
Insulin resistance;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2024;32(9):668-673
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between the homeostatic model assessment for insulin resistance index (HOMA-RI) and post-stroke cognitive impairment (PSCI) in patients with minor ischemic stroke (MIS) at 3 months after onset.Methods:Patients with acute MIS admitted to the Department of Neurology, Jiangsu Shengze Hospital from November 2019 to January 2022 were included prospectively. HOMA-RI was calculated based on fasting blood glucose and insulin. Cognitive function was evaluated using the Montreal Cognitive Assessment at 3 months after onset, and <26 points were defined as the presence of PSCI. Multivariate logistic regression analysis was used to determine the independent influencing factors of PSCI. Results:A total of 115 patients with MIS were enrolled, including 62 males (53.9%), aged 70.09±12.61 years. Among them, 71(61.74%) developed PSCI. Univariate analysis showed that there were significant differences in age, lipoprotein (a), HOMA-IR and its quartile classification, infarct side between PSCI group and non-PSCI group (all P<0.05). Multivariate logistic regression analysis showed that age (odds ratio [ OR] 1.052, 95% confidence interval [ CI] 1.015-1.089; P=0.005] and HOMA-RI (compared to the 1 st quartile, the 3 rd quartile: OR 1.012, 95% CI 2.306-4.171, P=0.043; the 4 th quartile: OR 2.125, 95% CI 1.085-4.163, P=0.028) were the independent risk factors for PSCI. Conclusion:High HOMA-RI is an independent risk factor for early onset of PSCI in patients with MIS, and the risk of PSCI increases with the increase of HOMA-RI.
