Function of follicular helper T cells in SARS-CoV-2 infection and vaccine immune responses
10.3969/j.issn.1673-4130.2025.22.017
- VernacularTitle:滤泡辅助性T细胞在SARS-CoV-2感染和疫苗免疫应答中的作用
- Author:
Rui CHANG
1
;
Xin SONG
;
Shuang BAI
;
Jian WANG
;
Junnan ZHANG
;
Wei ZHAO
Author Information
1. 首都医科大学燕京医学院,北京 101300
- Keywords:
T follicular helper cell;
SARS-CoV-2;
infection;
vaccine;
immune response
- From:
International Journal of Laboratory Medicine
2025;46(22):2779-2784
- CountryChina
- Language:Chinese
-
Abstract:
Follicular Helper T Cells(TFH)are a specialized subset of CD4+T cells that predominantly lo-calize within lymphoid follicles.These cells play a crucial role in facilitating B cell proliferation,differentia-tion,and antibody production,thereby thereby serving as a pivotal component of the adaptive immune re-sponse against infections.Given the significant function of TFH cells in regulating humoral immunity,they have become a focal point in the research of infectious diseases and related vaccine development in recent years.This review summarizes the surface markers of T follicular helper(Tfh)cells,their differentiation reg-ulatory mechanisms,and the latest research progress of Tfh cells in SARS-CoV-2 infection and vaccine stud-ies.It aims to provide new theoretical foundations and research insights for optimizing the design of SARS-CoV-2 vaccines and enhancing the cross-protection ability against SARS-CoV-2 variants.
