Changes of miR-27a-3p,miR-126,Semaphorin 3A and Ficolin-3 levels in patients with hypertension and their relationship with carotid intima-media thickness
10.3969/j.issn.1673-4130.2025.22.010
- VernacularTitle:高血压患者miR-27a-3p、miR-126、Semaphorin 3A、Ficolin-3水平变化及与颈动脉内膜中层厚度的关系
- Author:
Minzhi MA
1
;
Sheng ZHONG
;
Zhifu CHEN
Author Information
1. 宝鸡市人民医院心血管内科,陕西宝鸡 721000
- Keywords:
hypertension;
microribonucleic acid-27a-3p;
microribonucleic acid-126;
Semaphorin 3A;
fibrillar collagen 3;
carotid intima-media thickness
- From:
International Journal of Laboratory Medicine
2025;46(22):2743-2747
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum microRNA-27a-3p(miR-27a-3p),microRNA-126(miR-126),Semaphorin 3A,and fibrillar collagens 3(Ficolin-3)and their relationship with carotid intima-media thickness(CIMT)in patients with hypertension and to analyze the predictive value of the above indica-tors for CIMT thickening in patients with hypertensive.Methods A total of 96 hypertensive patients admitted to the hospital from July 2022 to July 2024 were selected as the study group.All patients underwent CIMT ex-amination.According to the CIMT results,they were divided into the thickening group(CIMT≥0.9 mm,35 cases)and the non-thickening group(CIMT＜0.9 mm,61 cases).Another 96 healthy individuals who under-went physical examinations during the same period were selected as the control group.The levels of serum miR-27a-3p,miR-126,Semaphorin 3A and Ficolin-3 in the study group and the control group,the thickening group and the non-thickening group were compared,as well as the differences in clinical data among each group.Logistic regression was used to analyze the risk factors of thickening of CIMT in patients with hyper-tension.The receiver operating characteristic(ROC)curve was plotted to analyze the predictive value of ser-um miR-27a-3p,miR-126,Semaphorin 3A,and Ficolin-3 for thickening of CIMT in patients with hyperten-sion,and the area under the curve(AUC)was obtained.Results Compared with the control group,the levels of serum miR-27a-3p,Semaphorin 3A and Ficolin-3 in the study group were lower(P＜0.05),and the level of serum miR-126 was higher(P＜0.05).Compared with the non-thickening group,the levels of serum miR-27a-3p,Semaphorin 3A and Ficolin-3 in the thickening group were lower(P＜0.05),and the expression level of serum miR-126 was higher(P＜0.05).The Logistic regression score results showed that low levels of ser-um miR-27a-3p,Semaphorin 3A,Ficolin-3,and high level of serum miR-126 were all independent risk factors for thickening of CIMT in patients with hypertension(OR=1.081,1.088,1.074,1.099,all P＜0.05).ROC curve analysis showed that the AUC of the combined prediction of thickening of CIMT in patients with hyper-tension by serum miR-27a-3p,miR-126,Semaphorin 3A,and Ficolin-3 was higher than that of the single detec-tion(P＜0.05),and the corresponding sensitivity of the combined detection was 97.14％and the specificity was 83.61％.Conclusion The levels of serum miR-27a-3p,Semaphorin 3A,and Ficolin-3 were lowly ex-pressed and the expression level of serum miR-126 were highly expressed in patients with hypertensive.The changes in these levels are closely related to the thickening of CIMT in patients with hypertension,and the combined prediction of the four has a higher value in predicting the thickening of CIMT in patients with hy-pertension.
