Predictive value of PLR,NLR and Fib expression in peripheral blood of stroke patients for deep vein thrombosis of lower limbs
10.3969/j.issn.1673-4130.2025.22.006
- VernacularTitle:脑卒中患者外周血PLR、NLR和Fib表达对下肢深静脉血栓形成的预测价值
- Author:
Yan HUANG
1
;
Hai ZHAO
;
Lei LIANG
;
Jun ZHANG
Author Information
1. 包头市中心医院神经康复中心,内蒙古包头 014040
- Keywords:
stroke;
platelet-to-leukocyte ratio;
neutrophil-to-lymphocyte ratio;
fibrinogen;
deep vein thrombosis of the lower limbs
- From:
International Journal of Laboratory Medicine
2025;46(22):2721-2725,2731
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between platelet-to-leukocyte ratio(PLR)and neutro-phil-to-lymphocyte ratio(NLR)and fibrinogen(Fib)levels in the peripheral blood of stroke patients and deep vein thrombosis(DVT)of the lower limbs,as well as their predictive value for wether DVT occurred in stroke patients.Methods A total of 106 stroke patients admitted to the hospital from January 1,2022 to January 30,2024 were retrospectively selected as the research subjects.According to the occurrence of DVT in the pa-tients,they were divided into the DVT group(n=38)and the non-DVT group(n=68),and the levels of PLR,NLR and Fib in the two groups were compared.Multivariate Logistic regression was used to analyze the influencing factors of DVT in stroke patients,and the receiver operating characteristic(ROC)curve was used to analyze the predictive value of PLR,NLR and Fib for DVT in stroke patients.Results The proportions of patients in the DVT group with NIHSS score＞14 points,GCS score＞8 points,and dehydrating drug use time＞5 days were higher than those in the non-DVT group(P＜0.05),and the levels of PLR,NLR and Fib were higher than those in the non-DVT group(P＜0.05).The results of Logistic regression analysis showed that the upregulation of PLR,NLR and Fib levels were all risk factors for DVT in stroke patients(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of the combined prediction of DVT in stroke patients by PLR,NLR and Fib was 0.890,with a sensitivity of 81.62％and a specificity of 88.78％.The com-bined detection AUC was higher than that predicted separately by PLR,NLR and Fib(Z=2.768,3.424,3.657,all P＜0.05).Conclusion Peripheral blood PLR,NLR and Fib levels are closely related to the occur-rence of DVT in stroke patients.]The combined application of PLR,NLR and Fib has a high predictive value in the occurrence of DVT in stroke patients and can be used as an effective biomarker to predict DVT occur-rence.
