Correlation between HMGB1 and inflammation,insulin resistance and placental vascular density in patients with gestational diabetes mellitus
10.3969/j.issn.1673-4130.2025.22.005
- VernacularTitle:妊娠期糖尿病患者HMGB1与炎症、胰岛素抵抗和胎盘血管密度的相关性
- Author:
Guohui FENG
1
;
Xiaorui LI
;
Ying HUANG
Author Information
1. 新疆维吾尔自治区人民医院产科,新疆乌鲁木齐 830000
- Keywords:
gestational diabetes mellitus;
high mobility group box 1 protein;
inflammation;
insulin resistance;
placental vascular density
- From:
International Journal of Laboratory Medicine
2025;46(22):2715-2720
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the level characteristics of high mobility group protein B1(HMGB1)in patients with gestational diabetes mellitus(GDM)and its correlations with inflammation,insulin resistance,and placental vascular density.Methods A total of 70 patients with GDM who were hospitalized and delivered in the department of obstetrics of this hospital from August 2021 to May 2024 were selected as the study group,and another 70 healthy pregnant women during the same period were selected as the control group.The general clinical data,fasting plasma glucose(FPG),insulin resistance-related indicators[fasting insulin(FINS),homeostasis model assessment of insulin resistance(HOMA-IR)],serum inflammatory factors[C reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],the levels of HMGB1 in pla-cental tissues and peripheral blood,and the placental microvascular density were compared between the two groups.Pearson correlation analysis was used to evaluate the correlations between the levels of HMGB1 in se-rum and placental tissues and insulin resistance,inflammatory factors,and placental vascular density.Results The levels of FPG,FINS,HOMA-IR,CRP,TNF-α,IL-6,the average integrated optical density(IOD)value of HMGB1 in serum and placental tissues,and the percentage of HMGB1-positive cells in the study group were all higher than those in the control group(P＜0.05),while the placental microvascular den-sity was lower than that in the control group(P＜0.05).Pearson correlation analysis showed that the serum HMGB1 level,the average IOD value of HMGB1 in placental tissues,and the percentage of HMGB1-positive cells in the study group were all positively correlated with the levels of HOMA-IR,CRP,TNF-α,and IL-6(P＜0.05),and negatively correlated with the placental microvascular density(P＜0.05).Conclusion The level of HMGB1 in peripheral blood and placental tissues of GDM patients is higher than that of healthy preg-nant women,and it is correlated with inflammatory factors,HOMA-IR and the placental microvascular density.
