Mitochondrial-related mechanisms and biomarkers in the process of physiological and pathological brain aging
10.3969/j.issn.1673-4130.2025.21.013
- VernacularTitle:生理性与病理性脑衰老过程中线粒体相关机制及生物标志物
- Author:
Xuezhe WANG
1
;
Junhan LIANG
;
Gengchen YU
;
Zixuan CHEN
;
Yulin DENG
Author Information
1. 北京理工大学医学技术学院,北京 100081
- Keywords:
brain aging;
mitochondria;
biomarker
- From:
International Journal of Laboratory Medicine
2025;46(21):2638-2647
- CountryChina
- Language:Chinese
-
Abstract:
Aging is a complex process triggered by multiple factors,characterized by the gradual decline of physiological and behavioral capabilities.Among various organs,the brain is particularly susceptible to aging effects.Brain aging not only leads to cognitive decline in the elderly but also increases the risk of neurodegen-erative diseases,resulting in reduced quality of life and increased social aging burdens.Therefore,it is essential to thoroughly investigate the mechanisms and biomarkers of both physiological and pathological brain aging to enable early prevention,monitoring,and intervention.Mitochondria play a crucial role in both physiological and pathological brain aging processes,making mitochondrial-related mechanisms and biomarkers key research directions in this field.This article reviews the main manifestations and mechanistic differences between physi-ological and pathological brain aging,summarizes mitochondrial mechanisms in brain aging,identifies mito-chondrial-associated biomarkers,and proposes health-promoting,mitochondria-targeting interventions.
