Research progress on the role of lipid metabolism in the pathogenesis of systemic lupus erythematosus
10.3969/j.issn.1673-4130.2025.21.012
- VernacularTitle:脂质代谢在系统性红斑狼疮发病机制中的作用研究进展
- Author:
Shouhua SONG
1
;
Zhenming ZHU
;
Kunyu CAO
;
Jiyu JU
Author Information
1. 山东第二医科大学基础医学院,山东潍坊 261053;青州市中医院检验科,山东青州 262500
- Keywords:
systemic lupus erythematosus;
abnormal lipid metabolism;
pathogenesis;
autoimmune disease
- From:
International Journal of Laboratory Medicine
2025;46(21):2633-2637,2647
- CountryChina
- Language:Chinese
-
Abstract:
Systemic lupus erythematosus(SLE)is a chronic autoimmune disease with complex etiology and diverse clinical manifestations.Its pathogenesis is complex,and the clinical treatment effect is not yet ide-al.Lipids are precursors of bioactive metabolites and components of cell membranes,exerting direct and indi-rect regulatory effects on signal transduction,gene regulation,and cell activation.Furthermore,lipids are one of the most significantly changing biomarkers in the serum of SLE patients.This article reviews the abnormal manifestations of lipid metabolism in SLE,the regulation of lipid metabolism and immune cell function,and possible therapeutic applications,providing new ideas for the diagnosis and treatment of SLE.
