Research progress on the epidemiological characteristics and transmission mechanisms of carbapenemase-encoding genes in CRECL
10.3969/j.issn.1673-4130.2025.21.011
- VernacularTitle:CRECL碳青霉烯酶编码基因流行特征与传播机制研究进展
- Author:
Guanqing CHEN
1
;
Xuemeng LI
;
Zhen GUO
;
Jun LIU
Author Information
1. 广东医科大学病原生物学实验室,广东湛江 524023
- Keywords:
carbapenem-resistant Enterobacter cloacae;
carbapenemase-encoding gene;
epidemiological characteristics;
resistance transmission mechanisms
- From:
International Journal of Laboratory Medicine
2025;46(21):2626-2632
- CountryChina
- Language:Chinese
-
Abstract:
The detection rate of carbapenem-resistant Enterobacter cloacae(CRECL)in clinical practice has risen steadily in recent years,and it has become one of the main pathogens of hospital-acquired infections.CRECL resistance is primarily driven by carbapenemase-encoding genes(CEG),which can spread through multiple mechanisms under the selective pressure of antibiotics and other environmental factors.This gene transfer significantly hampers antimicrobial treatment and infection control efforts.This review outlines the current understanding of CEG distribution in CRECL,key transmission pathways,and their public health im-plications.The findings aim to support the development of effective strategies for the prevention and manage-ment of CRECL infections.
