Clinical diagnostic value of sFlt-1/PLGF,UA and ALB for preeclampsia
10.3969/j.issn.1673-4130.2025.21.007
- VernacularTitle:sFlt-1/PLGF、UA、ALB对子痫前期的临床诊断价值
- Author:
Qilin TAN
1
;
Min JIANG
;
Chaohui DUAN
Author Information
1. 广东医科大学第一临床医学院,广东湛江 524023;广州医科大学附属妇女儿童医疗中心检验科,广东 广州 510623
- Keywords:
preeclampsia;
soluble fms-like tyrosine kinase-1;
placental growth factor;
uric acid;
albumin
- From:
International Journal of Laboratory Medicine
2025;46(21):2601-2606
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of fms-like tyrosine kinase-1(sFlt-1)to placental growth factor(PLGF)ratio(sFlt-1/PLGF),serum uric acid(UA)and albumin(ALB)for preeclampsia(PE).Methods A total of 110 pregnant women with PE who underwent prenatal examination,delivery and had complete data at the Affiliated Women's and Children's Medical Center of Guangzhou Medical University from January 2022 to July 2023 were selected as the PE group,and another 47 healthy pregnant women during the same period were selected as the control group.A retrospective analysis was conducted.The general data of the two groups of pregnant women,such as gestational weeks at delivery,blood pressure,body mass index(BMI),the second trimester and biochemical indicators,such as serum sFlt-1 and PLGF were compared.Lo-gistic regression Logistic regression was used to analyze the independent risk factors for the occurrence of PE,and the receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of sFlt-1/PLGF and biochemical indicators for PE.Results The levels of serum UA and sFlt-1/PLGF in the PE group were higher than those in the control group,while the level of serum ALB was lower than that in the control group,and the differences were statistically significant(P＜0.05).The results of ROC curve analysis showed that sFlt-1/PLGF,UA,and ALB all had certain diagnostic value for PE.The areas under the curve(AUC)were 0.854,0.825,and 0.778 respectively,and the AUC of the combination of the three was 0.894,which was higher than that of the single detection(P＜0.05).Conclusion The three indicators,sFlt-1/PLGF,UA and ALB,are all have reference value for predicting the occurrence and development of PE.The combined detec-tion of the three has a better diagnostic efficacy for PE..
