Retrospective epidemiological analysis of fungal infection of a hospital from 2018 to 2024
10.3969/j.issn.1673-4130.2025.21.005
- VernacularTitle:北京某院2018-2024年霉菌感染流行病学分析
- Author:
Zhihao LIU
1
;
Yali LIU
;
Lina GUO
;
Yao WANG
;
Ying ZHAO
;
Xiuli XIE
;
Wenjing LIU
;
Renyuan ZHU
;
Hongli SUN
;
Hongtao DOU
;
Dingding LI
;
Lingli LIU
;
Shuying YU
;
Menglan ZHOU
;
Qiwen YANG
;
Yingchun XU
;
Li ZHANG
Author Information
1. 中国医学科学院北京协和医学院/北京协和医院疑难重症及罕见病国家重点实验室检验科,北京 100730;重庆医科大学检验医学院,重庆 400016
- Keywords:
fungi;
aspergillus;
infection;
epidemiology;
mold
- From:
International Journal of Laboratory Medicine
2025;46(21):2588-2594
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the main epidemiological characteristics of fungal infection in this hospital in the past 7 years,and to provide reference for clinical treatment and prevention and control strategies of fun-gal infection.Methods The fungal data and clinical data of related patients isolated from clinical samples in Peking Union Medical College Hospital from early January 2018 to the end of May 2024 were selected,and the main epidemiological characteristics of fungal infection in this hospital were identified and described through multi-angle statistical analysis.Results A total of 4 479 patients with filamentous fungal infection were en-rolled.The proportion of male patients[57.5％(2 576/4 479)]was higher than that of female patients[42.5％(1 903/4 143)],mainly distributed in internal medicine,Intensive Care Unit(ICU)and emergency de-partment,among which internal medicine accounted for the highest proportion[50.0％(2 241/4 479)].About 90.0％of the specimens were from the lower respiratory tract,in addition to specimens from skin and soft tis-sue,tissue,ear and blood culture.In terms of seasonal distribution,there are more patients in winter.The fun-gi were mainly composed of Aspergillus,Mucor,Cerdosporium,Fusarium and Penicillium,among which As-pergillus was the most abundant,accounting for 74.6％of the total.Aspergillus fumigatus was the most a-bundant Aspergillus,accounting for 42.5％of the total Aspergillus(1 418/3 340).Among the related infec-tions caused by mold,Aspergillus was the most common in the lower respiratory tract,accounting for 76.8％.Among them,Aspergillus fumigatus accounted for the highest proportion(33.6％).98.6％of the molds infected the ear were Aspergillus,of which Aspergillus niger and Aspergillus terreus were the most common.Skin infections are mainly caused by Sporothrix schenckii,Trichophyton rubrum,Microsporum ca-nis.The results of in vitro drug sensitivity test showed that the four common Aspergillus isolated in this hos-pital were sensitive to voriconazole,and amphotericin B had better antifungal activity against Mucorales in vitro.Conclusion Based on the main epidemiological characteristics of fungal infections in this hospital,it is recommended that special attention be paid to the admission of patients in the respiratory department during the peak infection period in autumn and winter.In the treatment of fungal infections in different regions and on different body parts,attention should be paid to the differences in the distribution of bacterial species.
