Advances in the application of targeted protein degradation technology for cancer treatment
10.3969/j.issn.1673-4130.2025.21.002
- VernacularTitle:靶向蛋白降解技术在癌症治疗中的应用进展
- Author:
Fuli YAO
1
;
Zongying LI
;
Liuling SHEN
;
Dandan LI
Author Information
1. 重庆医科大学附属第二医院检验科,重庆 400010
- Keywords:
protein degradation;
proteolysis-targeting chimeras;
molecular glues;
targeted therapy
- From:
International Journal of Laboratory Medicine
2025;46(21):2571-2578
- CountryChina
- Language:Chinese
-
Abstract:
Targeted protein degradation(TPD)technology is an emerging approach that utilizes intracellu-lar proteasome or lysosome systems to eliminate disease-causing proteins,providing novel strategies for dis-ease treatment.Compared with conventional therapies,TPD has advantages such as targeting"undruppable"proteins,overcoming drug resistance and high selectivity.Among them,proteolysis-targeting chimeras(PRO-TACs)and molecular gels are representative methods,which have achieved significant progress in E3 ligase expansion,linker design,and delivery systems,and are gradually entering clinical research.PROTACs and mo-lecular glues can not only target key oncoproteins and overcome resistance,but also modulate immune respon-ses for therapeutic purposes,demonstrating broad clinical application prospects.This article reviews the re-search progress of the two types of technologies and their current application status in cancer treatment,and discusses their potential and challenges in efficacy monitoring and individualized medication from the perspec-tive of laboratory medicine.
