Application of platelet-nanoparticle complexes in the treatment of related diseases and current research status
10.3969/j.issn.1673-4130.2025.20.017
- VernacularTitle:PLT-NPs复合体在相关疾病治疗中的应用及研究现状
- Author:
Xinyue LIU
1
;
Zhaopei GUO
;
Pingjie SUN
;
Haocheng LI
;
Wei XIA
;
Linlin QU
Author Information
1. 北华大学医学技术学院,吉林吉林 132013
- Keywords:
nanoparticles;
platelet-rich plasma;
platelet aggregation
- From:
International Journal of Laboratory Medicine
2025;46(20):2524-2532
- CountryChina
- Language:Chinese
-
Abstract:
In vitro,platelets are readily activated,which complicates the process of quality control.In con-trast,nanoparticles possess distinct advantages due to their small size,high surface area ratio,biocompatibili-ty,and modifiability.These properties enable them to inhibit platelet aggregation through encapsulation or multi-modification,thereby ensuring the stability of quality control products for clinical platelet assays.This paper delineates the properties of the two existent forms of platelet-nanoparticle complexes,their synthesis principles,and their applications in the medical field.The text goes on to examine the preparation methods of some platelet-nanoparticle complexes and their applications in the fields of cancer therapy,wound healing,and immune disorders.It also explores the potential relationship between platelet-nanoparticle complexes and exo-some-nanoparticle complexes.Additionally,the future research directions of nanoparticles in platelet plasmino-genics are discussed in this paper,emphasizing the effects of nanoparticle concentration,size,and surface modi-fication on platelet aggregation.This provides a theoretical basis for the development of stable and controllable platelet plasminogenics.
