Research frontier and advancements of volatile organic compounds in urine as tumor biomarkers
10.3969/j.issn.1673-4130.2025.20.016
- VernacularTitle:尿液挥发性有机化合物作为肿瘤生物标志物的研究前沿与进展
- Author:
Funa SHI
1
;
Pingxi ZHAO
;
Famei QI
Author Information
1. 甘肃省人民医院检验中心,甘肃兰州 730000
- Keywords:
volatile organic compounds;
cancer;
biomarkers;
urine
- From:
International Journal of Laboratory Medicine
2025;46(20):2518-2523,2532
- CountryChina
- Language:Chinese
-
Abstract:
There is an urgent need for noninvasive biomarkers for early detection and dynamic monitoring of tumor.Urinary volatile organic compounds(VOCs)have become a research hotspot due to their easy acces-sibility,high sensitivity and ability to reflect metabolic abnormalities.VOCs originate from host metabolism,transformation of exogenous substances and microbial activities,and their changes are related to cancer meta-bolic reprogramming.This article reviews the generation mechanisms,detection technologies and clinical ap-plications of urinary VOCs.Advances in detection technologies have significantly improved the detection effi-ciency of urinary VOCs,and clinical studies have shown high sensitivity in diseases such as bladder and pros-tate cancer.However,urinary VOCs still face challenges such as lack of standardised methods,external inter-ferences and small sample size limitations,although they have shown potential to differentiate between differ-ent types of tumor.In the future,it is necessary to promote the translation of urinary VOCs from the laborato-ry to the clinic through the integration of multi-omics,large-scale validation driven by artificial intelligence and the development of miniaturised devices,and to build an integrated system for"early screening-diagnosis-ther-apeutic effect monitoring".
