Association analysis between antenatal WBC and the risk of late pregnancy premature rupture of membranes combined with histological chorioamnionitis
10.3969/j.issn.1673-4130.2025.20.014
- VernacularTitle:产前WBC和孕晚期胎膜早破合并组织学绒毛膜羊膜炎风险的关联分析
- Author:
Yan CHEN
1
;
Shuying ZHANG
;
Lijuan JIANG
;
Yu CHEN
Author Information
1. 苏州大学附属第三医院检验科,江苏常州 213003
- Keywords:
premature rupture of membranes in late pregnancy;
white blood cell count;
histological chorioamnionitis
- From:
International Journal of Laboratory Medicine
2025;46(20):2507-2512
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between antenatal white blood cell count(WBC)and the risk of histological chorioamnionitis(HCA)in pregnant women with late pregnancy premature rupture of membranes(PROM).Methods A retrospective analysis was performed on totally 118 pregnant women with PROM in late pregnancy from March 2018 to August 2021 in the hospital.They were divided into HCA group and non-HCA group according to the presence or absence of HCA.The general clinical data,laboratory indica-tors and delivery outcomes of the two groups were compared.Univariate and multivariate Logistic regression were used to analyze the association between prenatal WBC and HCA risk.Generalized additive models were used for curve fitting,and segmented regression models were used to further explain the nonlinear relationship between maternal prenatal WBC and HCA risk.Results The prenatal WBC of the HCA group was signifi-cantly higher than that of the non-HCA group(P＜0.001).After adjusting for covariates,elevated prenatal WBC increased the risk of HCA,with an OR of 1.190(95％CI:1.006-1.406,P=0.042).Curve fitting showed that there was a nonlinear relationship between prenatal WBC and HCA risk,and the log-likelihood ratio test of WBC at the inflection point 13.5×109/L(95％CI:11.75-14.56)was statistically significant(P=0.029).For the three groups of prenatal WBC,the risk of HCA in pregnant women gradually increased with the increase of WBC level,which was 0.314(95％CI:0.200-0.456)in the normal group,0.439(95％CI:0.252-0.645)in the high group,and 0.682(95％CI:0.354-0.893)in the elevated group.Conclusion The higher the prenatal WBC of pregnant women with PROM in late pregnancy,the greater the risk of HCA,but there is no simple linear relationship between the two,and there is a threshold effect.
