Value of serum sTREM-1,IL-17,and sFasL in evaluating severity and prognosis of neonatal infection
10.3969/j.issn.1673-4130.2025.20.013
- VernacularTitle:血清sTREM-1、IL-17、sFasL对新生儿感染疾病严重程度及预后的评估价值
- Author:
Tianwen ZHU
1
;
Shuiqin GU
;
Yuting HUANG
Author Information
1. 南京中医药大学常熟附属医院新生儿科,江苏常熟 215500
- Keywords:
neonatal infection;
soluble triggering receptor expressed on myeloid cell-1;
interleukin-17;
soluble Fas ligand;
severity;
prognosis
- From:
International Journal of Laboratory Medicine
2025;46(20):2502-2506
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of serum soluble triggering receptor expressed on myeloid cell-1(sTREM-1),interleukin-17(IL-17),and soluble Fas ligand(sFasL)in evaluating severity and prognosis of neonatal infection.Methods From November 2022 to November 2024,a total of 105 neonates with infections who visited the Department of Pediatrics in the hospital were labeled as infection group,and 105 healthy neo-nates were labeled as control group.Based on the severity of neonatal infection,the affected children were as-signed into extremely critical group,critical group,and non critical group.Based on prognosis,the affected children were grouped into adverse group and good group.Enzyme linked immunosorbent assay(ELISA)was used to measured serum sTREM-1,IL-17,and sFasL.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum sTREM-1,IL-17,and sFasL for prognosis.Results The serum levels of sTREM-1,IL-17,and sFasL in the infection group were significantly higher than those in the control group(P＜0.05).The serum sTREM-1,IL-17,and sFasL decreased in serum of extremely critical group,critical group,and non critical group in sequence(P＜0.05).Spearman correlation showed that serum sTREM-1,IL-17,and sFasL levels were positively correlated with disease severity(r=0.601,0.592,0.523,P＜0.05).The proportion of cesarean section,serum levels of sTREM-1,IL-17,and sFasL in the poor group were higher than those in the good group(P＜0.05),and the Apgar score was lower than that in the good group(P＜0.05).Logistic regression revealed that cesarean section,sTREM-1,IL-17,and sFasL were all factors affecting the adverse prognosis of neonatal infections(P＜0.05).ROC curve showed that the area under the curve(AUC)of serum sTREM-1,IL-17,sFasL,and their combined detection in predicting adverse prognosis of neonatal in-fections was 0.781,0.788,0.768,and 0.879,respectively.The AUC of joint prediction was greater than those of individual prediction(Zcombination-sTREM-1=2.238,P=0.025,Zcombination-IL-17=2.014,P=0.044,Zcombination-sFasL=2.248,P=0.025).Conclusion Serum sTREM-1,IL-17,and sFasL levels in neonates with infections are man-ifestly elevated,and they are closely related to the severity and prognosis.
