Changes in serum Cav-1 and Mcl-1 levels and their clinical significance in patients with sepsis-induced acute lung injury
10.3969/j.issn.1673-4130.2025.20.006
- VernacularTitle:脓毒症所致急性肺损伤患者血清Cav-1、Mcl-1水平变化及临床意义
- Author:
Peng YUE
1
;
Minghai LIU
Author Information
1. 淄博市第一医院急诊科,山东淄博 255200
- Keywords:
sepsis;
acute lung injury;
caveolin-1;
myeloid cell leukemia-1;
disease severity;
prog-nosis
- From:
International Journal of Laboratory Medicine
2025;46(20):2464-2468,2473
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and clinical significance of serum caveolin-1(Cav-1)and myeloid cell leukemia-1(Mcl-1)levels in patients with sepsis-induced acute lung injury(S-ALI).Methods A total of 198 patients with S-ALI admitted to the hospital from January 2021 to September 2024 were selected as the S-ALI group.They were divided into mild S-ALI group(52 cases),moderate S-ALI group(72 cases),and severe S-ALI group(74 cases)based on disease severity(oxygenation index).According to the 28 day prognosis after admission,they were divided into death group(65 cases)and survival group(133 cases).Addi-tionally,70 healthy individuals during the same period were selected as the control group.Serum Cav-1 and Mcl-1 levels were measured using enzyme-linked immunosorbent assay.The correlation between serum Cav-1 and Mcl-1 levels and the oxygenation index in S-ALI patients was analyzed using Spearman's correlation.Mul-tivariate Logistic regression and receiver operating characteristic(ROC)curve analysis were performed to e-valuate the relationship between serum Cav-1 and Mcl-1 levels and the prognosis of S-ALI patients,as well as their predictive value.Results Serum Cav-1 level in the S-ALI group was lower than that in the control group(P＜0.05),while Mcl-1 level was higher than that in the control group(P＜0.05).In S-ALI patients,the oxy-genation index was negatively correlated with serum Cav-1 level(P＜0.05)and positively correlated with Mcl-1 level(P＜0.05).Serum Cav-1 level progressively decreased(P＜0.05),and Mcl-1 level progressively increased across the mild,moderate,and severe S-ALI groups(P＜0.05).The 28 day mortality rate among the 198 S-ALI patients was 32.83％(65/198).Cav-1 was identified as an independent protective factor(P＜0.05),while Mcl-1 was an independent risk factor for mortality in S-ALI patients(P＜0.05).The area under the curve of the combined prediction of serum Cav-1 and Mcl-1 levels for the mortality in S-ALI patients was 0.881,which was larger than 0.798 and 0.779 of Cav-1 and Mcl-1 alone(P＜0.05).Conclusion Decreased serum Cav-1 level and increased Mcl-1 level are closely associated with increased disease severity and mortality in S-ALI patients.The combined detection of serum Cav-1 and Mcl-1 levels has high prognostic value for S-ALI patients.
