Predictive value of TyG,CAR,and miR-21 for the prognosis of ischemic heart failure patients with type 2 diabetes mellitus
10.3969/j.issn.1673-4130.2025.19.015
- VernacularTitle:TyG、CAR及miR-21对缺血性心力衰竭合并2型糖尿病患者预后的预测价值
- Author:
Mingru ZHANG
1
;
Panfei LI
;
Changping LI
Author Information
1. 上海市松江区泗泾镇社区卫生服务中心全科,上海 201601
- Keywords:
triglyceride-glucose;
C-reactive protein to albumin ratio;
microRNA-21;
ischemic heart failure;
type 2 diabetes mellitus
- From:
International Journal of Laboratory Medicine
2025;46(19):2397-2401
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of triglyceride-glucose index(TyG),C-reactive pro-tein to albumin ratio(CAR),and microRNA-21(miR-21)for the prognosis of ischemic heart failure(IHF)patients with type 2 diabetes(T2DM).Methods The medical records of totally 400 IHF patients with T2DM who were admitted to the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University from January 2022 to December 2023 were selected and divided into a favorable prognosis group(n=318)and a poor prog-nosis group(n=82)based on whether major adverse cardiovascular events(MACE)occurred within 6 months after diagnosis.General information,along with TyG,CAR,and miR-21 levels,was gathered for both groups.Univariate analysis and multivariate Logistic regression were applied to identify the factors influencing poor prognosis in IHF patients with T2DM.Receiver operating characteristic(ROC)curves were plotted to assess the predictive capacity of TyG,CAR,and miR-21 for poor prognosis in these patients.Results Univari-ate analysis showed that there were statistically significant differences in the history of hypertension,history of coronary heart disease,advanced age,TyG,CAR,and miR-21 between the two groups(P＜0.05).Multiva-riate Logistic regression indicated that advanced age,coronary artery disease,TyG,CAR,and miR-21 were in-dependent risk factors for poor prognosis in IHF patients with T2DM(P＜0.05).The area under the curve of the combined detection of TyG,CAR,and miR-21 for poor prognosis in IHF patients with T2DM was 0.841,with sensitivity of 0.814 and specificity of 0.707.Conclusion The levels of TyG,CAR and miR-21 in IHF pa-tients with T2DM and poor prognosis are increased,and the three are closely related to adverse cardiovascular events.Combined detection can be used as an auxiliary indicator for the prognosis of IHF patients with T2DM.
