Diagnostic value of peripheral blood lymphocyte subsets,IL-6,and PCT levels for postoperative recurrence of gastric cancer
10.3969/j.issn.1673-4130.2025.17.012
- VernacularTitle:外周血淋巴细胞亚群、IL-6、PCT水平对胃癌术后复发的诊断价值研究
- Author:
Ting ZHANG
1
;
Jiadong LIU
Author Information
1. 黄石市中心医院(湖北理工学院附属医院)医学检验科,湖北 黄石 435000;肾脏疾病发生与干预湖北省重点实验室,湖北 黄石 435000;肿瘤分子诊断与治疗黄石市重点实验室,湖北 黄石 435000
- Keywords:
gastric cancer;
postoperative recurrence;
lymphocyte subsets;
interleukin-6 procalcito-nin;
diagnostic value
- From:
International Journal of Laboratory Medicine
2025;46(17):2115-2119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of peripheral blood lymphocyte subsets,interleu-kin-6(IL-6)and procalcitonin(PCT)levels for postoperative recurrence of gastric cancer.Methods A total of 206 patients with gastric cancer who have undergone radical operation from April 2021 to May 2023 in the Huangshi Central Hospital(Affiliated Hospital of Hubei Polytechnic University)were selected as the study subjects.The patients were divided into recurrent group(58 cases)and non-recurrent group(148 cases)ac-cording to whether they had recurrence or not.Venous blood samples were drawn from the recurrent group and the non-recurrent group,and the flow cytometry was used to measure peripheral blood T-cell subsets,nat-ural killer cells,and B cells,while the circulating enhanced fluorescence immunoluminescence method was em-ployed to detect peripheral blood IL-6 and PCT levels.The expression of various indicators was compared in the two groups,and the receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of peripheral blood lymphocyte subsets,as well as IL-6 and PCT levels,for postoperative recurrence of gastric cancer.Results There were no statistically significant differences in CD3+,CD3+CD8+,CD3+CD4+,CD4+/CD8+between recurrent group and non-recurrent group(P>0.05).The levels of CD3-CD19+,CD3-CD56+,IL-6,PCT in recurrent group were higher than those in non-recurrent group(P<0.05).The area un-der the curve(AUC)of CD3-CD19+,CD3-CD56+,IL-6,and PCT for diagnosing postoperative recurrence of gastric cancer was 0.656,0.682,0.888,and 0.868,respectively.The AUC of the combination of these four markers for diagnosing postoperative recurrence of gastric cancer was 0.919,which was superior to each indi-vidual marker(P<0.05).Conclusion Peripheral blood lymphocyte subsets,as well as levels of IL-6 and PCT,are closely associated with postoperative recurrence in patients with gastric cancer.Combined detection has a higher efficacy in diagnosing postoperative recurrence in gastric cancer patients.
