Correlation between intestinal flora imbalance and serum IL-6,SAA and D-lactic acid levels in COPD patients with pulmonary infection
10.3969/j.issn.1673-4130.2025.17.010
- VernacularTitle:COPD合并肺部感染患者肠道菌群失调与血清IL-6、SAA和D-乳酸水平的相关性分析
- Author:
Jingjing GUO
1
;
Aixia ZHANG
Author Information
1. 徐州市中心医院,江苏 徐州 221000
- Keywords:
chronic obstructive pulmonary disease;
intestinal flora imbalance;
interleukin-6;
serum amyloid A;
D-lactic acid
- From:
International Journal of Laboratory Medicine
2025;46(17):2105-2109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between intestinal flora imbalance and serum interleukin-6(IL-6),serum amyloid A(SAA)and D-lactic acid levels in chronic obstructive pulmonary disease(COPD)pa-tients with pulmonary infection.Methods The case data of totally 148 COPD patients with pulmonary infec-tion who were treated in the hospital from June 2022 to June 2023 were collected.According to the presence or absence of intestinal flora imbalance,they were divided into intestinal flora imbalance group(n=41)and in-testinal flora non-imbalance group(n=107).The levels of serum IL-6,SAA and D-lactic acid and distribution of intestinal flora in the two groups were detected,and the correlation between intestinal flora imbalance and levels of serum IL-6,SAA and D-lactic acid was analyzed.Results The levels of serum IL-6,SAA and D-lactic acid in intestinal flora imbalance group were higher than those in intestinal flora non-imbalance group(P<0.05).Eubacterium,Lactobacillus and Bifidobacterium counts in intestinal flora imbalance group were less than those in intestinal flora non-imbalance group(P<0.05),while Enterococcus and Escherichia coli counts were more than those in intestinal flora non-imbalance group(P<0.05).In intestinal flora imbalance group,there were 14 cases with degree Ⅰ imbalance(degree Ⅰ group),6 cases with degree Ⅱ imbalance(degree Ⅱgroup)and 21 cases with degree Ⅲ imbalance(degree Ⅲ group).The levels of serum IL-6,SAA,and D-lac-tate increased sequentially in the degree Ⅰ group,degree Ⅱ group and degree Ⅲ group(P<0.05).Eubacteri-um,Lactobacillus and Bifidobacterium counts were negatively correlated with serum IL-6,SAA and D-lactic acid levels(P<0.05),while Escherichia coli and Enterococcus counts were positively correlated with serum IL-6,SAA and D-lactic acid levels(P<0.05).Conclusion There is a correlation between intestinal flora im-balance and serum IL-6,SAA and D-lactic acid levels in COPD patients with pulmonary infection,and IL-6,SAA and D-lactic acid levels could be used as effective indicators to evaluate the degree of intestinal flora im-balance.
