Applications and advances of culturomics in disease microbiome research
10.3969/j.issn.1673-4130.2025.17.006
- VernacularTitle:培养组学在疾病微生物组研究中的应用与进展
- Author:
Jia XU
1
;
Yingmiao ZHANG
;
Zhongxin LU
Author Information
1. 华中科技大学同济医学院附属武汉中心医院检验科,湖北 武汉 430014;湖北中医药大学检验学院,湖北 武汉 430065
- Keywords:
culturomics;
sequencing technology;
microbiome;
disease research;
clinical applica-tions
- From:
International Journal of Laboratory Medicine
2025;46(17):2079-2085
- CountryChina
- Language:Chinese
-
Abstract:
With the proposal and implementation of the Human Microbiome Project,the role of microbial communities in the occurrence and development of diseases has been increasingly valued.Sequencing technolo-gy has been widely applied in related research and has made great progress.However,there are also shortcom-ings such as high detection thresholds and inability to obtain viable bacteria.As an emerging technology,cul-turomics aims to isolate and cultivate as many different bacterial communities as possible by simulating the survival environments of bacteria and employing various culture conditions,and accurately identify the corre-sponding bacteria.This technique is widely applied in the study of microbial community characteristics across different diseases.This paper reviews the application of culturomics in disease research and explores its prom-ising integration with other omics technologies in microbiome research.This technology is widely used for studying the microbial community characteristics of different diseases.This article reviews the application of culturomics in various disease research and explores its promising prospects in microbial community research when combined with other omics techniques.
