Correlation of serum pepsinogen level with gastric intestinal metaplasia and Helicobacter pylori infection
10.3969/j.issn.1673-4130.2025.16.017
- VernacularTitle:血清胃蛋白酶原水平与胃黏膜肠上皮化生、幽门螺杆菌感染的相关性
- Author:
Tingting WANG
1
;
Jia MING
Author Information
1. 胜利油田中心医院检验科/东营市血液病诊疗重点实验室,山东东营 257099
- Keywords:
pepsinogen;
Helicobacter pylori;
intestinal metaplasia;
infection;
relevance
- From:
International Journal of Laboratory Medicine
2025;46(16):2014-2021
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum pepsinogen(PG)level and gastric in-testinal metaplasia,Helicobacter pylori(Hp)infection.Methods A total of 140 patients with gastric intesti-nal metaplasia who were diagnosed and treated in the hospital from February 2022 to February 2024 were se-lected as the research objects.According to the pathological type,they were divided into simple intestinal met-aplasia group(n=45),atypical intestinal metaplasia group(n=52),and gastric cancer group(n=43).The general information,Hp infection subtype and PG level of the three groups were compared.Generalized addi-tive model(GAM)was used to analyze the relationship between PG level and gastric cancer.Multivariate Lo-gistic regression was used to analyze the influencing factors of gastric cancer.The levels of PG in patients with different pathological types of gastric intestinal metaplasia and different subtypes of Hp infection were com-pared.The mediating effect of PG level between Hp infection subtypes and gastric cancer was analyzed.Gener-alized linear model was used to analyze the effect of PG level on the association between Hp infection subtypes and gastric cancer.Results There were significant differences in drinking strong tea,spicy food,Hp infection subtypes,gastrin-17(G-17)and thioredoxin 1(TRX-1)(P＜0.05).Compared with the simple intestinal met-aplasia group and the atypical intestinal metaplasia group,the PG Ⅰ level and PG Ⅰ to PG Ⅱ ratio(PGR)in the gastric cancer group were decreased(P＜0.05),and the PG Ⅱ level was increased(P＜0.05).GAM anal-ysis showed that PG Ⅰ,PGⅡ and PGR were statistically significant variables(P＜0.05),and their effects on gastric cancer showed a non linear curve relationship.Drinking strong tea,spicy food,Hp type Ⅰ infection,G-17 and TRX-1 were independent risk factors for gastric cancer(P＜0.05),and PGR was an independent pro-tective factor for gastric cancer(P＜0.05).The level of PG Ⅰ and PGR in patients with Hp type Ⅰ infection were lower than those in patients with Hp type Ⅱ infection,and the level of PG Ⅱ was higher than that in pa-tients with Hp type Ⅱ infection(P＜0.05).The results of mediating effect analysis showed that PG Ⅰ,PGⅡand PGR had mediating effects between infection subtypes and gastric cancer.The positive association between Hp type Ⅰ infection and gastric cancer was gradually weakened with the increase of PG Ⅰ level and PGR in the total population and in different genders.With the increase of PG Ⅱ level,the positive correlation between Hp type Ⅰ infection and gastric cancer gradually strengthened.Conclusion The level of PG is significantly different in patients with different pathological types of gastric mucosa intestinal metaplasia.The level of PG Ⅰ and PGR are decreased,while the level of PG Ⅱ is increased in patients with gastric cancer.There is a non linear curve relationship between PG level and gastric cancer.PG level plays a mediating role in the rela-tionship between Hp infection subtypes and gastric cancer,and its changes may affect the association between Hp infection and gastric cancer.
