Analysis of serum CCL23 and SUR1 levels and their prognostic value in patients with acute intracerebral hemorrhage
10.3969/j.issn.1673-4130.2025.16.004
- VernacularTitle:急性脑出血患者血清CCL23、SUR1水平及其预后价值分析
- Author:
Xudong WANG
1
;
Jue WANG
;
Xiaochun MU
Author Information
1. 黑龙江省第三医院神经外科,黑龙江黑河 164000
- Keywords:
acute cerebral hemorrhage;
CC chemokine ligand 23;
sulfonylurea receptor 1;
prognosis
- From:
International Journal of Laboratory Medicine
2025;46(16):1941-1946
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of CC chemokine ligand 23(CCL23)and sulfony-lurea receptor 1(SUR1)in patients with acute cerebral hemorrhage(ACH)and their predictive value for prognosis.Methods A total of 97 patients with ACH admitted to the hospital from May 2020 to May 2023 were collected as the case group.According to the National Institutes of Health Stroke Scale(NIHSS)score,the patients were divided into mild group(n=26),moderate group(n=41)and severe group(n=30).Ac-cording to the prognosis at 6 months after treatment,the patients were divided into a good prognosis group(n=71)and a poor prognosis group(n=26).During the same period,70 healthy physical examination people were randomly selected as the control group.The serum levels of CCL23 and SUR1 were detected by enzyme-linked immunosorbent assay.Spearman rank correlation analysis was used to analyze the correlation between serum CCL23,SUR1 levels and disease severity.Multivariate Logistic regression was used to analyze the rela-tionship between serum CCL23 and SUR1 levels and poor prognosis of ACH patients.The receiver operating characteristic curve was used to evaluate the predictive value of serum CCL23 and SUR1 for poor prognosis of ACH patients.Results Compared with the control group,the serum levels of CCL23 and SUR1 were in-creased in the case group(P＜0.05).Compared with the mild group,the moderate group and severe group had significant increases in the serum levels of CCL23 and SUR1(P＜0.05),and the severe group had a more significant increase than the moderate group(P＜0.05).Serum CCL23 and SUR1 levels were positively corre-lated with the severity of the disease(rs=0.672,0.634,P＜0.05).Compared with mild patients,the risk of poor prognosis increased in moderate and severe patients,with OR of 1.432(95％CI:1.125-1.822)and 1.863(1.322-2.625),respectively.Elevated serum CCL23 and SUR1 levels were risk factors for poor prog-nosis in ACH patients,OR were 1.513(95％CJ:1.206-1.901)and 1.439(95％CI:1.096-1.890)respec-tively.The area under the curve of serum CCL23,SUR1 and their combination in predicting poor prognosis of ACH patients were 0.839,0.823 and 0.911,respectively.The combined predictive value of the two indicators was higher than that of single index(Z=1.664,1.958,P=0.012,0.008).Conclusion The serum levels of CCL23 and SUR1 are up-regulated in ACH patients,which are related to the severity and prognosis of ACH.Early combined detection of CCL23 and SUR1 can assist clinical judgment and predict the risk of poor prognosis.
