Advances in the application of gene copy number alteration detection technology in lymphoma
10.3969/j.issn.1673-4130.2025.15.012
- VernacularTitle:基因拷贝数变异检测技术在淋巴瘤中的应用研究进展
- Author:
Yu PENG
1
;
Shuang CHEN
;
Tingting JIANG
;
Can LIN
;
Longrong RAN
;
Xuelian WU
;
Lian LI
;
Liangmei LI
;
Xinyi TANG
;
Yakun ZHANG
;
Huiyu XIANG
;
Junxi LIU
;
Dan JI
;
Zailin YANG
Author Information
1. 重庆大学附属肿瘤医院血液肿瘤中心,重庆 400030
- Keywords:
gene copy number alteration;
lymphoma;
clinical application
- From:
International Journal of Laboratory Medicine
2025;46(15):1860-1866
- CountryChina
- Language:Chinese
-
Abstract:
Lymphoma is a highly heterogeneous malignancy characterized by complex molecular regulatory mechanisms that result in significant differences in aggressiveness and prognosis across its subtypes.Gene copy number alteration(CNA)analysis,an emerging technology,has become a pivotal tool in the precision re-search and management of lymphoma.By detecting DNA deletions,amplifications,and chromosomal copy number changes,CNA analysis addresses the limitations of traditional cytogenetic techniques,enhances the ac-curacy of subtype classification,and aids in evaluating tumor heterogeneity and disease progression.This re-view provides a comprehensive summary of CNA detection methods and their applications in lymphoma,with a focus on recent advancements in the field.It offers a comparative analysis of CNA detection techniques and discusses their role in precision diagnosis,subtype classification,monitoring disease progression,predicting therapeutic resistance,and assessing prognosis.Additionally,the review explores the potential applications of CNA analysis in uncovering molecular regulatory mechanisms,optimizing therapeutic strategies,and impro-ving patient survival outcomes.
