Predictive value of serum KLF4 levels combined with plasma atherogenic index for prognosis of acute middle cerebral artery occlusion patients undergoing endovascular therapy
10.3969/j.issn.1673-4130.2025.15.011
- VernacularTitle:血清KLF4水平联合血浆致动脉硬化指数对急性大脑中动脉闭塞患者血管内介入治疗预后的预测价值
- Author:
Xiaowei FENG
1
;
Fan YANG
;
Yunbin LIU
Author Information
1. 宝鸡市人民医院神经内科,陕西 宝鸡 721000
- Keywords:
acute middle cerebral artery occlusion;
Krüppel-like factor 4;
plasma atherogenic index;
endovascular therapy;
prognosis
- From:
International Journal of Laboratory Medicine
2025;46(15):1855-1859
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of serum Krüppel-like factor 4(KLF4)level com-bined with plasma atherogenic index(AIP)for prognosis in patients with acute middle cerebral artery occlu-sion(AMCAO)undergoing endovascular therapy(EVT).Methods A total of 187 AMCAO patients who un-derwent EVT in Baoji People's Hospital from January 2021 to August 2023 were selected as the AMCAO group.The AMCAO patients were further categorized based on one-year post-EVT outcomes into a poor prognosis group(n=64)and a good prognosis group(n=123).A total of 95 healthy volunteers who under-went physical examination in Baoji People's Hospital during the same period were selected as the control group.Serum KLF4 levels were measured using enzyme-linked immunosorbent assay,and the AIP was calcu-lated.Multivariate unconditional Logistic regression was applied to analyze the relationship between serum KLF4,AIP,and EVT prognosis,while receiver operating characteristic curves were used to evaluate the com-bined predictive value of KLF4 and AIP for prognosis in AMCAO patients.Results Compared with control group,AMCAO group had lower serum KLF4 levels and higher AIP(P<0.05).The 1-year poor prognosis rate of 187 AMCAO patients after EVT was 34.22%(64/187).Compared with good prognosis group,the poor prognosis group had lower KLF4 levels and higher AIP(P<0.05).High national institutes of health stroke scale score,delayed onset-to-recanalization time,and elevated AIP were independent risk factors for poor EVT prognosis in AMCAO patients,while high KLF4 was an independent protective factor(P<0.05).The combined detection of KLF4 and AIP of area under the curve in predicting EVT prognosis was 0.866,sig-nificantly higher than of KLF4(0.788)or AIP(0.769)alone(P<0.05).Conclusion Lower serum KLF4 levels and elevated AIP are associated with poor EVT prognosis in AMCAO patients.Combined measurement of serum KLF4 and AIP has high predictive value for EVT prognosis in these patients.
