Intravascular volume in children with primary nephrotic syndrome using fractional excretion of filtered sodium
10.3969/j.issn.1673-4130.2025.15.005
- VernacularTitle:利用滤过钠排泄分数研究原发性肾病综合征患儿血管内容量
- Author:
Juan LIANG
1
;
Yafei ZHUANG
;
Jin CHENG
;
Shujuan ZHEN
;
Yuheng LIANG
;
Ping ZENG
;
Hu SHAO
;
Fengjun GUAN
Author Information
1. 徐州医科大学附属医院儿科,江苏 徐州 221006
- Keywords:
primary nephrotic syndrome;
intravascular volume;
fractional excretion of filtered sodi-um;
edema;
course of the disease
- From:
International Journal of Laboratory Medicine
2025;46(15):1820-1824,1830
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the intravascular volume at different levels of edema and disease course by the fractional excretion of filtered sodium(FeNa)of children with primary nephrotic syndrome(PNS).Methods A total of 172 children with newly diagnosed PNS who were hospitalized in the Affiliated Hospital of Xuzhou Medical University from September 2022 to September 2024 were selected and divided into non-e-dema group(n=51),mild edema group(n=43),moderate edema group(n=46)and severe edema group(n=32)according to the degree of edema at the time of admission.A total of 40 healthy children who underwent physical examination during the same period were selected as the healthy control group.Serum creatinine,ser-um sodium were detected before and after treatment.Urine samples were collected to detect urine creatinine,urine sodium,FeNa was calculated and compared according to the results,and the degree of edema was recor-ded.24 h urine samples were collected on the same day to detect 24 h urine protein quantification and 24 h u-rine volume.Results On day 1 to 2 of the course of the disease,about 12%of the PNS children had FeNa<0.2%,indicating insufficient intravascular volume,which was mainly concentrated in the severe edema group.The moderate,severe edema group had a significantly lower FeNa level than the non-edema group,mild edema group,and healthy control group(P<0.01).The moderate edema group had a significant increase in FeNa on days 6 to 7 of the course of the disease,and the severe edema group had a significant increase in Fena on days 11 to 12 of the course of the disease(P<0.01).Conclusion Intravascular volume of PNS children with mod-erate to severe edema is often reduced,and intravascular volume may be insufficient in severe edema.PNS chil-dren with moderate to severe edema have increased intravascular volume with the extension of the course of disease and the improvement of the condition.
