Serum Linc02381 expression in patients with colorectal cancer and its diagnostic value
10.3969/j.issn.1673-4130.2025.14.002
- VernacularTitle:结直肠癌患者血清Linc02381表达及其诊断价值
- Author:
Lei SHEN
1
;
Ming ZHENG
;
Zijie TANG
;
Erlin CHEN
Author Information
1. 南通大学附属医院医学检验科,江苏 南通 226000
- Keywords:
colorectal cancer;
Linc02381;
tumor markers
- From:
International Journal of Laboratory Medicine
2025;46(14):1670-1675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of serum Linc02381 in patients with colorectal cancer(CRC)and its diagnostic value.Methods The relative expression levels of serum Linc02381 in CRC patients,patients with benign colorectal diseases and healthy individuals undergoing physical examination were detected by real-time fluorescence quantitative PCR.The relationship between the expression of serum Linc02381 in CRC patients and clinicopathological characteristics was analyzed.The levels of serum carcinoembryonic anti-gen(CEA),carbohydrate antigen 19-9,cytokeratin 19 fragment antigen 21-1(CYFRA21-1)and carbohydrate antigen 72-4 were detected by chemiluminescent immunoassay.The receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of serum Linc02381 and commonly used clinical tumor mark-ers for CRC.Results The relative expression level of serum Linc02381 in CRC group was compared with those in benign colorectal diseases group and healthy control group,and the difference was statistically signifi-cant(P<0.05).The relative expression levels of serum Linc02381 in CRC patients before and after the opera-tion were 2.918(2.173,3.811)and 1.809(1.495,2.014),respectively,and the difference was statistically significant(P<0.05).There was a statistically significant difference in histological stage between patients with high expression of serum Linc02381 and those with low expression of serum Linc02381(P<0.05).The results of the ROC curve showed that the area under the curve of the combined diagnosis of CRC by Linc02381,CEA and CYFRA21-1 could reach 0.905.Conclusion The combined application of serum Linc02381 with commonly used clinical such as CEA and CYFRA21-1 can improve the diagnostic value of CRC patients.
