Study on the relationship between serum TXNRD1 and PAK1 levels and insulin resistance and adverse pregnancy outcomes in patients with gestational diabetes mellitus
10.3969/j.issn.1673-4130.2025.14.001
- VernacularTitle:妊娠期糖尿病患者血清TXNRD1、PAK1水平与胰岛素抵抗和不良妊娠结局的关系研究
- Author:
Ying WANG
1
;
Juhong XU
;
Min CAI
Author Information
1. 宝鸡第三医院检验科,陕西 宝鸡 721004
- Keywords:
gestational diabetes mellitus;
thioredoxin reductase 1;
p21-activated kinase 1;
insulin re-sistance
- From:
International Journal of Laboratory Medicine
2025;46(14):1665-1669,1675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum thioredoxin reductase 1(TXNRD1),p21-activated kinase 1(PAK1)levels and insulin resistance(IR)and adverse pregnancy outcomes(APO)in pa-tients with gestational diabetes mellitus(GDM).Methods Eighty patients with GDM admitted to Baoji Third Hospital from January 2019 to January 2024 were selected as the GDM group.They were divided into the APO group(25 cases)and the non-APO group(55 cases)based on whether APO occurred.Eighty healthy pregnant women who came to the hospital for prenatal examination recently in a 1∶1 ratio were selected as the control group.The levels of serum TXNRD1 and PAK1 were detected by enzyme-linked immunosorbent assay.The correlation between the levels of serum TXNRD1 and PAK1 in patients with GDM and the homeo-static model assessment of insulin resistance(HOMA-IR)was analyzed through Pearson correlation analysis.Multivariate unconditional Logistic regression was used to analyze the relationship between serum TXNRD1 and PAK1 levels and APO in patients with GDM,and the receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of serum TXNRD1 and PAK1 levels for them.Results Compared with the control group,HOMA-IR and the levels of serum TXNRD1 and PAK1 in the GDM group increased,and the difference was statistically significant(P<0.05).Pearson correlation analysis showed that the levels of serum TXNRD1 and PAK1 in patients with GDM were positively correlated with HOMA-IR(r=0.783,0.790,P<0.001).The results of multivariate unconditional Logistic regression analysis showed that high TXNRD1 and high PAK1 were independent risk factors for APO in patients with GDM(P<0.05).The re-sults of ROC curve analysis showed that the area under the curve(AUC)of serum TXNRD1 and PAK1 levels alone and in combination for predicting APO in GDM patients was 0.785,0.789,and 0.900,respectively.The combined AUC of serum TXNRD1 and PAK1 levels for predicting APO in GDM patients was the largest(Z=2.148,2.454,P=0.032,0.014).Conclusion The levels of serum TXNRD1 and PAK1 in patients with GDM are related to IR and APO.The combination of levels of serum TXNRD1 and PAK1 have a certain pre-dictive efficacy for APO in patients with GDM.
