Correlation between serum FABP4,ANGPTL4,CA125 and the cardiac function classification and recurrence after radiofrequency ablation in patients with paroxysmal atrial fibrillation
10.3969/j.issn.1673-4130.2025.13.018
- VernacularTitle:血清FABP4、ANGPTL4、CA125与阵发性心房颤动患者心功能分级及射频消融术后复发的相关性
- Author:
Fenli ZHANG
1
;
Jing WANG
Author Information
1. 西安交通大学第一附属医院心血管内科,陕西西安 710061
- Keywords:
paroxysmal atrial fibrillation;
fatty acid binding protein 4;
angiopoietin like protein 4;
carbohydrate antigen 125;
cardiac function grading;
radiofrequency ablation
- From:
International Journal of Laboratory Medicine
2025;46(13):1636-1640
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum fatty acid binding protein 4(FABP4),an-giopoietin like protein 4(ANGPTL4),carbohydrate antigen 125(CA125)and the cardiac function classifica-tion and recurrence after radiofrequency ablation in patients with paroxysmal atrial fibrillation(PAF).Meth-ods Totally 126 patients with PAF who underwent radiofrequency ablation in the First Affiliated Hospital of Xi'an Jiaotong University from March 2022 to March 2023 were selected as the PAF group.They were divided into the mild group and the severe group according to the cardiac function classification,and were further di-vided into the recurrence group and the non-recurrence group based on the postoperative follow-up results.Another 116 healthy individuals who underwent physical examinations in this hospital during the same period were selected as the control group.The levels of serum FABP4,ANGPTL4 and CA125 were detected by en-zyme-linked immunosorbent assay(ELISA),the correlations among the levels of serum FABP4,ANGPTL4 and CA125 in patients with PAF were analyzed by Pearson method,and the influencing factors of postopera-tive recurrence in patients with PAF were analyzed by multivariate Logistic regression.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum FABP4,ANGPTL4,and CA125 levels for postoperative recurrence in patients with PAF.Results Compared with the control group,the levels of serum FABP4 and CA125 in the PAF group were increased(P＜0.05),and the level of ANGPTL4 was de-creased(P＜0.05).Compared with the mild group,the levels of serum FABP4 and CA125 in the severe group increased(P＜0.05),and the level of ANGPTL4 decreased(P＜0.05).The levels of serum ANGPTL4 were negatively correlated with those of FABP4 and CA125(r=-0.467,—0.513,both P＜0.001),and the level of serum FABP4 was positively correlated with that of CA125(r=0.436,P＜0.001).The levels of serum FABP4 and CA125 in the recurrence group were increased compared with those in the non-recurrence group(P＜0.05),and the level of ANGPTL4 was decreased(P＜0.05).Hypertension,the use of antiarrhythmic drugs,serum FABP4,CA125,and ANGPTL4 were the influencing factors for postoperative recurrence in pa-tients with PAF(P＜0.05).The combined prediction value of serum FABP4,ANGPTL4 and CA125 for re-currence after radiofrequency ablation in patients with PAF was superior to that of each index alone(P＜0.05).Conclusion The serum levels of FABP4 and CA125 in PAF patients increase,while the level of AN-GPTL4 decreases.All three indicators are closely related to cardiac function grading and recurrence after ra-diofrequency ablation.
