The relationship between systemic immune-inflammation index and prognosis of patients with AECOPD complicated with type Ⅱ respiratory failure
10.3969/j.issn.1673-4130.2025.13.017
- VernacularTitle:系统性免疫炎症指数与AECOPD并发Ⅱ型呼吸衰竭患者预后的关系
- Author:
Xin WANG
1
;
Zhanhua ZHANG
;
Sanhong ZHANG
Author Information
1. 西安交通大学附属红会医院急诊医学科,陕西西安 710100
- Keywords:
systemic immune-inflammation index;
acute exacerbation of chronic obstructive pulmonary disease;
type Ⅱ respiratory failure;
prognosis
- From:
International Journal of Laboratory Medicine
2025;46(13):1631-1635
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between systemic immune-inflammation index(SII)and prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicat-ed with type Ⅱ respiratory failure.Methods A total of 92 patients with AECOPD complicated with type Ⅱrespiratory failure admitted to Honghui Hospital Affiliated to Xi'an Jiaotong University from February 2022 to February 2024 were selected as the research subjects.According to the 28-day survival status,they were di-vided into the survival group(n=69)and the death group(n=23).The counts of neutrophils,lymphocytes and platelets of the patients were detected by the fully automatic hematology analyzer,and SII was calculated.The receiver operating characteristic curve was used to analyze the predictive value of SII for the prognosis of patients.Multivariate Logistic regression analysis was used to explore the influencing factors of prognosis in patients.Results The platelet count,neutrophil count,SII and acute physiology and chronic health evaluationⅡ(APACHE Ⅱ)score in the survival group were lower than those in the death group,while the lymphocyte count in the survival group was higher than that in the death group,the differences were statistically signifi-cant(P＜0.05).In patients with AECOPD complicated with type Ⅱ respiratory failure,SII was positively correlated with APACHEⅡ score(r=0.612,P＜0.001).The areas under the curve(AUC)of platelets,neu-trophils and lymphocytes in predicting the prognosis of patients with AECOPD complicated with type Ⅱ re-spiratory failure were 0.776(95％CI:0.731-0.826),0.849(95％CI:0.799-0.894),and 0.732(95％CI:0.687-0.782),respectively,the AUC of SII in predicting the prognosis of patients with AECOPD complicat-ed with type Ⅱ respiratory failure was 0.925(95％CI:0.880-0.975).The proportion of death groups com-bined with heart diseases and blood urea nitrogen(BUN),B-type natriuretic peptide(BNP)were higher than those in the survival group,while hemoglobin(Hb)was lower than that in the survival group,and the differ-ences were statistically significant(P＜0.05).Combined cardiac diseases,BUN,Hb,BNP and SII were the in-fluencing factors for the prognosis of patients with AECOPD complicated with type Ⅱ respiratory failure(P＜0.05).Conclusion The increase of SII is related to the prognosis of patients with AECOPD complicated with type Ⅱ respiratory failure,and it has certain predictive value for the prognosis of patients with AECOPD complicated with type Ⅱ respiratory failure.
