The relationship between SII,RDW and 25(OH)D levels and frailty index in elderly patients with type 2 diabetes mellitus
10.3969/j.issn.1673-4130.2025.13.016
- VernacularTitle:老年2型糖尿病患者SII、RDW及25(OH)D水平与衰弱指数的关系
- Author:
Zhihua ZHOU
1
;
Qian WANG
;
Nan YANG
;
Xiaoying WANG
;
Hong GONG
;
Meng GUO
;
Jieqiong ZHAO
Author Information
1. 西安交通大学第二附属医院健康管理部,陕西西安 710000
- Keywords:
elderly type 2 diabetes mellitus;
systemic immune-inflammation index;
red blood cell dis-tribution width;
25-hydroxy-vitamin-D;
frailty index
- From:
International Journal of Laboratory Medicine
2025;46(13):1626-1630
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between systemic immune-inflammation index(SII),red blood cell distribution width(RDW),25-hydroxy-vitamin-D[25(OH)D]levels and frailty index in elderly pa-tients with type 2 diabetes mellitus(T2DM).Methods A total of 197 elderly patients with T2DM admitted to the hospital from March 2023 to March 2024 were collected as the research subjects.The patients were divided into the frailty group(106 cases)and the non-frailty group(91 cases)according to the scores of the clinical frailty scale.The clinical data and the levels of SII,RDW and 25(OH)D of the two groups were compared.Pearson correlation analysis was used to analyze the correlations between the levels of SII,RDW and 25(OH)D and the frailty index of elderly patients with T2DM.Logistic regression was used to analyze the influencing factors of frailty in elderly patients with T2DM.Results Compared with the non-frailty group,the proportion of women,the history of falls within 1 year,and the age of the frailty group increased,while the body mass in-dex and the proportion of men decreased,and the differences were statistically significant(P＜0.05).The SII and RDW levels in the non-frailty group were lower than those in the frailty group,and the 25(OH)D level was higher than that in the frailty group,and the differences were statistically significant(P＜0.05).Pearson correlation analysis showed that SII and RDW levels were positively correlated with frailty index,and 25(OH)D level was negatively correlated with frailty index in elderly T2DM patients(P＜0.05).Logistic regression analysis showed that female,age ≥ 74.25 years old,SII≥ 938.36,RDW≥ 15.19％,and 25(OH)D≥48.42 nmol/L were independent risk factors for frailty in elderly T2DM patients(P＜0.05).Conclusion The levels of SII,RDW and 25(OH)D in elderly patients with T2DM are related to the frailty index.
