The predictive value of serum CRP/Alb ratio,CysC,PCT and SAA levels for urinary tract infection after percutaneous nephrolithotripsy in patients with upper urinary tract calculi
10.3969/j.issn.1673-4130.2025.13.014
- VernacularTitle:血清CRP/Alb比值、CysC、PCT及SAA水平对上尿路结石患者经皮肾镜碎石取石术后尿路感染的预测价值
- Author:
Xiaosheng HAN
1
;
Suimei WANG
;
Huan XIA
Author Information
1. 海口市人民医院检验科,海南海口 570208
- Keywords:
C-reactive protein/albumin ratio;
cystatin C;
percutaneous nephrolithotripsy;
urinary tract infection
- From:
International Journal of Laboratory Medicine
2025;46(13):1614-1619
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of serum C-reactive protein(CRP)/albumin(Alb)ratio,cystatin C(CysC),procalcitonin(PCT),and serum amyloid A(SAA)levels for urinary tract infection after percutaneous nephrolithotripsy in patients with upper urinary tract calculi.Methods A retrospective se-lection was made of 127 patients with upper urinary tract calculi who underwent percutaneous nephrolithotrip-sy in this hospital from January 2021 to January 2024 as the research subjects.The patients were divided into the infection group(n=66)and the non-infection group(n=61)according to their postoperative urinary tract infection conditions.Analyze the distribution of pathogenic bacteria in the infection group,as well as the com-parison of clinical data,CRP/Alb ratio,CysC,PCT and SAA levels between the two groups.Multivariate Lo-gistic regression was used to analyze the influencing factors of postoperative urinary tract infection in patients.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of CRP/Alb ratio,CysC,PCT and SAA levels for postoperative urinary tract infection in patients.Results The pathogenic bacte-ria in the infection group were mainly Gram-negative bacteria[44(66.67％)].The proportions of smoking history and operation duration ≥60 minutes in the infection group were higher than those in the non-infection group,and the difference was statistically significant(P＜0.05).The CRP/Alb ratio,CysC,SAA and PCT levels in the infection group were higher than those in the non-infection group,and the difference was statisti-cally significant(P＜0.05).The results of multivariate Logistic regression analysis showed that smoking his-tory,operation duration ≥60 min,upregulation of CRP/Alb ratio,CysC,SAA,and PCT levels were risk fac-tors for postoperative urinary tract infection in patients(P＜0.05).The results of ROC curve analysis showed that the combined prediction of CRP/Alb ratio,CysC,SAA and PCT for postoperative urinary tract infection in patients had a sensitivity of 89.41％,a specificity of 90.22％,and an area under the curve(AUC)of 0.933.The AUC of the combined prediction was higher than that of the individual predictions of CysC,SAA and PCT(Z=3.564,2.846,2.644,P＜0.05).Conclusion The serum CRP/Alb ratio,CysC,PCT,and SAA levels have important predictive value for urinary tract infection after percutaneous nephrolithotripsy in patients with up-per urinary tract calculi.
