The relationship between chromosomal karyotypes and reproductive factor levels in peripheral blood and adverse pregnancies in women
10.3969/j.issn.1673-4130.2025.13.012
- VernacularTitle:外周血染色体核型和生殖因子水平与女性不良妊娠的关系
- Author:
Nan XIE
1
;
Mei ZHOU
;
Li QIAO
Author Information
1. 西安交通大学第一附属医院榆林医院检验科,陕西榆林 719000
- Keywords:
chromosomal karyotypes;
reproductive factor;
adverse pregnancy outcomes
- From:
International Journal of Laboratory Medicine
2025;46(13):1603-1607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between chromosomal karyotypes and reproductive factor levels in peripheral blood and adverse pregnancies in women.Methods A total of 105 pregnant women who received prenatal care and delivered at Yulin Hospital,the First Affiliated Hospital of Xi'an Jiaotong Uni-versity and Yulin Traditional Chinese Medicine Hospital from January 2020 to June 2024 were selected as the research subjects.Through the follow-up observation of pregnant women,there were 29 cases of pregnant women with adverse pregnancies(adverse pregnancy group)and 76 cases of pregnant and parturient women with normal pregnancies(good pregnancy group).The karyotypes of peripheral blood chromosomes and the levels of reproductive factors,as well as their correlations with adverse pregnancy outcomes,were analyzed re-spectively in the adverse pregnancy group and the good pregnancy group.Results There was a statistically significant difference in the proportion of autosomes and sex chromosomes in the number and structure of pe-ripheral blood between the adverse pregnancy group and the good pregnancy group(P＜0.05).The anti-Müllerian hormone(AMH)level in the adverse pregnancy group was higher than that in the good pregnancy group,while estradiol(E2)and progesterone(P)levels were lower than those in the good pregnancy group,and the differences were statistically significant(P＜0.05).Abnormalities in autosomal number,autosomal structure,sex chromosome number,sex chromosome structure,and AMH were all positively correlated with adverse pregnancy outcomes(r=0.369,0.445,0.528,0.665,0.785,P＜0.05).E2 and P were negatively cor-related with adverse pregnancy outcomes(r=-0.865,—0.562,P＜0.05).Conclusion Peripheral blood chromosomal karyotypes and reproductive factor levels are related to adverse pregnancies in women.By under-standing the relationship between these biomarkers and chromosomal abnormalities,adverse pregnancy out-comes can be better predicted and managed,and the accuracy of fertility treatment can be improved.
