Predictive value of serum CCL21 and TSGF for liver metastasis of colorectal cancer
10.3969/j.issn.1673-4130.2025.12.017
- VernacularTitle:血清CCL21、TSGF对结直肠癌肝转移的预测价值
- Author:
Bo WANG
1
;
Lei LIU
;
Qingni CHENG
Author Information
1. 西安市第三医院普通外科,陕西西安 710018
- Keywords:
colorectal cancer;
liver metastasis;
CC chemokine ligand 21;
tumor specific growth fac-tor;
survival analysis
- From:
International Journal of Laboratory Medicine
2025;46(12):1503-1507
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of serum CC chemokine ligand 21(CCL21)and tumor specific growth factor(TSGF)for liver metastasis of colorectal cancer(CRC).Methods From January 2018 to January 2023,120 CRC patients in Xi'an Third Hospital were selected as the research subjects and di-vided into the non-metastasis group(n=68)and the metastasis group(n=52)according to whether liver me-tastasis occurred.Additionally,135 healthy subjects who underwent physical examinations in the hospital dur-ing the same period were selected as the control group.The level of CCL21 was detected by enzyme-linked im-munosorbent assay(ELISA),and the level of TSGF was detected by colorimetry.Univariate and multivariate Logistic regression analyses were used to analyze the influencing factors of liver metastasis in CRC.The re-ceiver operating characteristic(ROC)curve was used to analyze the predictive value of CCL21 and TSGF lev-els for liver metastasis of CRC,and the Z-test was used to compare the differences in the area under the curve(AUC).The Kaplan-Meier method was used to conduct survival analysis on CRC patients with liver metasta-sis,and the Log-rank test was used to analyze the differences in survival curves between groups.Results Compared with the control group,the levels of CCL21 and TSGF in the patients increased after the occurrence of CRC,and further increased after liver metastasis,and the differences were statistically significant(P＜0.05).Liver metastasis in CRC patients was correlated with the degree of differentiation,depth of invasion and lymph node metastasis of the patients(P＜0.05).Invasion depth(T3-T4),lymph node metastasis,and elevated levels of CCL21 and TSGF were independent risk factors for liver metastasis in CRC patients(P＜0.05).The AUC of the combined diagnosis of liver metastasis in CRC patients by CCL21 and TSGF was 0.909,which was superi-or to the separate diagnosis of the two(0.780,0.790),and the differences were statistically significant(P＜0.05).The survival rate of the high-expression group of CCL21(48.00％)was lower than that of the low-ex-pression group,and the survival rate of the high-expression group of TSGF(50.00％)was lower than that of the low-expression group(83.33％),and the differences were statistically significant(Log-rank x2=6.429,6.344;P=0.011,0.012).Conclusion The levels of serum CCL21 and TSGF in CRC patients are relatively high.The combined detection of the two has certain predictive value for the occurrence of liver metastasis.
