Evaluation value of PDGF,MCP-1 and ANGPTL4 levels in aqueous humor for anti-VEGF therapeutic efficacy of neovascular glaucoma
10.3969/j.issn.1673-4130.2025.12.009
- VernacularTitle:房水PDGF、MCP-1、ANGPTL4水平对新生血管性青光眼抗VEGF治疗疗效的评估价值
- Author:
Honglan YANG
1
;
Dongping YAO
Author Information
1. 监利市人民医院眼科,湖北监利 433300
- Keywords:
neovascular glaucoma;
platelet-derived growth factor;
monocyte chemotactic protein-1;
angiopoietin-like protein 4;
anti-vascular endothelial growth factor therapy
- From:
International Journal of Laboratory Medicine
2025;46(12):1455-1460
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the evaluation value of platelet-derived growth factor(PDGF),monocyte chemoattractant-1(MCP-1)and angiopoietin-like protein-4(ANGPTL4)in aqueous humor for therapeutic ef-ficacy and disease progression of anti-vascular endothelial growth factor(VEGF)treatment in neovascular glaucoma(NVG).Methods A total of 220 patients(220 eyes)with NVG in this hospital from January 2020 to January 2024 were selected as the NVG group,and 248(248 eyes)patients who underwent cataract surgery were selected as the control group.According to the Teich classification criteria for iris neovascularization,pa-tients were divided into grade Ⅱ(n=102),grade Ⅲ(n=73),and grade Ⅳ(n=45).According to the thera-peutic effect,they were further divided into the effective group(n=186)and the ineffective group(n=34).The levels of PDGF,MCP-1 and ANGPTL4 were detected by enzyme-linked immunosorbent assay(ELISA),and the influencing factors of ineffective anti-VEGF treatment were analyzed by multivariate Logistic regres-sion.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of PDGF,MCP-1 and ANGPTL4 for the effectiveness of anti-VEGF treatment.Results The levels of PDGF,MCP-1 and AN-GPTL4 in the NVG group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The levels of PDGF,MCP-1 and ANGPTL4 in grade Ⅲ patients were higher than those in grade Ⅱ patients,and those in grade Ⅳ patients were higher than those in grade Ⅲ and grade Ⅱ pa-tients,and the differences were statistically significant(P＜0.05).After anti-VEGF treatment,the levels of PDGF,MCP-1 and ANGPTL4 in the effective group decreased more significantly than those in the ineffective group(P＜0.05).Elevated PDGF,MCP-1 and ANGPTL4 were independent risk factors for ineffective anti-VEGF treatment(P＜0.05).The area under the curve(AUC)of aqueous humor PDGF,MCP-1,and AN-GPTL4 alone in predicting the effectiveness of anti-VEGF treatment were 0.812,0.790,and 0.802 respective-ly.The AUC of the combined prediction was 0.948,which was superior to the individual predictions of each(P＜0.05).Conclusion The levels of PDGF,MCP-1 and ANGPTL4 in the aqueous humor of NVG patients gradually increase with the progression of the disease,and the higher levels of these three factors may have re-sistance effect to anti-VEGF therapy.
