Relationship between serum NfL,Endocan,BAFF and epilepsy secondary to acute cerebral infarction and its predictive value
10.3969/j.issn.1673-4130.2025.12.002
- VernacularTitle:血清NfL、Endocan、BAFF与急性脑梗死继发癫痫的关系及其预测价值
- Author:
Linlin LI
1
;
Li LIU
;
Linyi YANG
;
Yunwei ZHANG
Author Information
1. 遂宁市中心医院神经内科,四川遂宁 629000
- Keywords:
neurofilament light chain protein;
endothelial cell specific molecule-1;
B cell activating fac-tor;
acute cerebral infarction;
epilepsy
- From:
International Journal of Laboratory Medicine
2025;46(12):1414-1418,1424
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship and predictive value between serum neurofilament light chain protein(NfL),endothelial cell specific molecule-1(Endocan),B cell activating factor(BAFF)and epi-lepsy secondary to acute cerebral infarction(ACI).Methods From June 2020 to June 2023,135 patients with secondary epilepsy due to ACI admitted to the hospital were included in the epilepsy group,and 90 ACI pa-tients without secondary epilepsy admitted during the same period were included in the non-epilepsy group.The general data of the two groups and the levels of serum NfL,Endocan and BAFF were determined and compared.Multivariate Logistic regression was used to analyze the related influencing factors of epilepsy sec-ondary to ACI.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum NfL,Endocan and BAFF for epilepsy secondary to ACI.Results Compared with non-epilepsy group,the age,the proportion of infarction lesions involving cortex,the proportion of National Institutes of Health Stroke Scale(NISSH)score≥15 points,the proportion of infarct volume＞10 cm3,the proportion of family history of epilepsy,and serum NfL,Endocan and BAFF were significantly increased in epileptic group(P＜0.05).Among patients with infarction lesions involving cortex and NISSH score ≥15 points,the expression levels of serum NfL,Endocan,and BAFF were significantly higher in those with epilepsy than in those without epilepsy(P＜0.05).Multivariate Logistic regression analysis showed that infarction involving the cortex,NISSH score ≥15 points,elevated serum NfL,Endocan and BAFF were risk factors for secondary epilepsy in ACI(P＜0.05).The results of ROC curve analysis showed that the area under the curve and specificity of the combined prediction of serum NfL,Endocan,and BAFF for secondary epilepsy in ACI were superior to those of individual detection or the combined detection of the two(P＜0.05).Conclusion The high expression of serum NfL,Endocan and BAFF are risk factors for secondary epilepsy in ACI.The combined detection of the three has a high predictive value for secondary epilepsy in ACI.
