Mechanisms of action of Helicobacter pylori colonization factors
10.3969/j.issn.1673-4130.2025.11.017
- VernacularTitle:幽门螺杆菌定植因子的作用机制
- Author:
Mingming ZHAO
1
;
Lizhen DONG
;
Zichao JIA
;
Chengxue WANG
;
Yamin CHAI
;
Wei LUO
Author Information
1. 天津医科大学总医院空港医院检验科,天津 300450
- Keywords:
Helicobacter pylori;
urease;
flagellum;
outer membrane protein;
biofilm
- From:
International Journal of Laboratory Medicine
2025;46(11):1370-1374,1408
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori(Hp)is a major pathogen that causes peptic ulcer,mucosa-associated tissue lymphoma and gastric cancer.Adhesion colonization is a prerequisite for the pathogenesis of Hp.After infec-tion,Hp first uses urease to neutralize gastric acid,and then it adapts to the environment through motility and chemotactic swimming of flagella.Finally,Hp adheres to gastric epithelial cells through outer membrane pro-teins.Some outer membrane proteins have the biological effect of transporting virulence factors,mediating in-flammation and assisting Hp to produce pathological changes on human body.This paper reviews the mecha-nism of main colonization factors of Hp.
