Advances of 5-fluorouracil resistance mechanism and new therapeutic strategies in the treatment of colon cancer
10.3969/j.issn.1673-4130.2025.11.016
- VernacularTitle:结肠癌治疗中5-氟尿嘧啶耐药机制和新治疗策略的研究进展
- Author:
Tingting LI
1
;
Ziyun ZHAO
Author Information
1. 山东第二医科大学医学检验学院,山东潍坊 261053
- Keywords:
colon cancer;
5-fluorouracil;
drug resistance;
mechanism
- From:
International Journal of Laboratory Medicine
2025;46(11):1364-1369
- CountryChina
- Language:Chinese
-
Abstract:
Colon cancer is a common malignant tumor in the human digestive system.5-fluorouracil(5-FU)is a first-line treatment for colon cancer,which can be used alone or in combination with other chemo-therapy drugs.However,with the increase of 5-FU use time,colon cancer cells are prone to develop primary and secondary resistance to 5-FU.In recent years,a lot of significant research progress has been made on 5-FU resistance related genes at different levels,such as molecular mechanisms,animal models,and clinical trials.This article reviews the latest research progress on 5-FU resistance in terms of DNA damage repair mecha-nisms,increased expression of adenosine triphosphate(ATP)binding box transporter,abnormal signaling pathways,abnormal nucleoside metabolizing enzymes,forkhead box protein M1(FOXM1),etc.,in order to provide reference and basis for the treatment of colon cancer.
