Prognostic value of thromboelastography combined with MPV in patients with ischemic stroke after dual antiplatelet therapy
10.3969/j.issn.1673-4130.2025.11.011
- VernacularTitle:血栓弹力图联合MPV对缺血性脑卒中患者双联抗血小板治疗后复发的预测价值
- Author:
Haoying YANG
1
;
Yezi DU
;
Fan DUAN
Author Information
1. 三二〇一医院输血科,陕西汉中 723000
- Keywords:
thromboelastography;
mean platelet volume;
ischemic stroke;
antiplatelet therapy
- From:
International Journal of Laboratory Medicine
2025;46(11):1336-1340,1346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of thromboelastography(TEG)combined with mean platelet volume(MPV)in patients with ischemic stroke after dual antiplatelet therapy.Methods A to-tal of 130 cases with ischemic stroke who received dual antiplatelet therapy in the hospital from November 2021 to December 2023 were selected as the study subjects.According to the results of follow-up 6 months af-ter treatment,they were divided into non-recurrence group(n=98)and recurrence group(n=32).Venous blood was collected from all patients for TEG and MPV tests.TEG parameters[coagulation reaction time(R),clot formation time(K),hemagglutination rate(α angle),maximum clot intensity(MA value),compos-ite index(CI)]and MPV of the two groups were compared.The predictive value of TEG combined with MPV for postoperative recurrence of patients was analyzed by receiver operating characteristic(ROC)curve.Multi-variate Logistic regression analysis was used to explore the influencing factors of relapse.Results R and K in recurrence group were lower than those in non-recurrence group,α angle,MA value,CI and MPV were higher than those in non-relapsed group,with statistical significance(P＜0.05).ROC curve analysis showed that the area under curve of the combined prediction of α angle,MA value,and MPV for recurrence after dual antiplate-let therapy in ischemic stroke patients was 0.938,which was higher than predicted separately(Z=9.983,6.711,5.036,all P＜0.001).The proportions of smoking history,atrial fibrillation,diabetes and deep vein thrombosis in relapse group were higher than those in non-recurrence group(P＜0.05).Multivariate Logistic regression analysis showed that diabetes mellitus,α Angle ≥69.39°,MA value ≥67.07 mm,MPV≥10.39 fL were all risk factors for recurrence after dual antiplatelet therapy in ischemic stroke patients(P＜0.05).Con-clusion The α angle of thrombologram,MA value and MPV can be used as important indicators to predict the recurrence of patients with ischemic stroke after dual antiplatelet therapy,and the combined application of the three is more effective.
